Kazemeini Sarah, Nadeem-Tariq Ahmed, Luthra Anahat, Suha Raisa, Turna Arun, Easterly Jennifer, Pokharel Sahara, Muqaddas Sophia, Kazemeini Monia
Medical Education, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, USA.
Otolaryngology - Head and Neck Surgery, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, USA.
Cureus. 2025 Jun 19;17(6):e86343. doi: 10.7759/cureus.86343. eCollection 2025 Jun.
Facial trauma repair frequently results in scarring that can significantly impact psychological well-being, particularly in highly visible areas, such as the face. While topical agents provide a non-invasive means of optimizing scar outcomes, clinical guidance regarding their use remains limited, especially for diverse skin types. This narrative review synthesizes findings from PubMed, Google Scholar, and Embase, prioritizing randomized controlled trials, meta-analyses, and expert consensus. Evidence supports the use of silicone gel, corticosteroids, retinoids, vitamin C, niacinamide, and onion extract for scar modulation. A timeline-based model was developed to guide agent selection across healing phases, emphasizing early intervention after re-epithelialization and tailored regimens for patients with Fitzpatrick skin types IV-VI. This review proposes a phase-specific approach to facial scar optimization that integrates skin phototype considerations. Further research is needed to validate the safety and efficacy of combinatory topical regimens across diverse populations.
面部创伤修复常常会导致瘢痕形成,这会对心理健康产生重大影响,尤其是在面部等高度暴露的部位。虽然局部用药提供了一种优化瘢痕治疗效果的非侵入性方法,但关于其使用的临床指导仍然有限,特别是对于不同的皮肤类型。这篇叙述性综述综合了来自PubMed、谷歌学术和Embase的研究结果,重点关注随机对照试验、荟萃分析和专家共识。有证据支持使用硅胶凝胶、皮质类固醇、维甲酸、维生素C、烟酰胺和洋葱提取物来调节瘢痕。我们开发了一个基于时间线的模型,以指导在愈合各阶段的用药选择,强调上皮化后尽早干预,并为 Fitzpatrick皮肤类型IV-VI的患者制定个性化方案。本综述提出了一种针对面部瘢痕优化的阶段特异性方法,该方法综合考虑了皮肤光型。需要进一步研究来验证联合局部用药方案在不同人群中的安全性和有效性。