Chondroblastoma-Like Chondroma of Soft Tissue Arising at the Outer Canthus: A Case Report.

Chondroblastoma-like chondroma is a rare variant of soft tissue chondroma that can mimic bone-origin chondroblastoma histologically. Its occurrence in the periocular region is extremely rare. We report a 31-year-old woman with a painless, slowly enlarging nodule at the right outer canthus. Histopathological evaluation revealed a dermal tumor composed of polygonal mononuclear cells, multinucleated giant cells, and chondroid matrix with "chicken-wire" calcifications. Immunohistochemistry supported a diagnosis of chondroblastoma-like chondroma. This case highlights the diagnostic complexity of periocular soft tissue chondromas and underscores the critical role of histopathology in achieving accurate diagnosis and informing treatment decisions.