急性单核细胞白血病患者的血流感染：一例罕见病例报告。
bloodstream infection in a patient with acute monocytic leukemia: A rare case report.
作者信息
Qi Tian, Zhou Mi, Chen Xingchun, Xu Heping, Pan Weihua, Ding Xinying
机构信息
Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Children's Hospital of Soochow University, Suzhou, China.
出版信息
Med Mycol Case Rep. 2025 Jul 16;49:100718. doi: 10.1016/j.mmcr.2025.100718. eCollection 2025 Sep.
A 26-year-old male with relapsed acute monocytic leukemia (AML-M5) in China developed fungemia during consolidation chemotherapy. Diagnosis was confirmed by MALDI-TOF MS and ITS sequencing. Antifungal susceptibility revealed resistance to echinocandins but sensitivity to amphotericin B. Serial (1,3)-β-D-glucan monitoring correlated with disease progression. This case highlights diagnostic challenges and therapeutic dilemmas in regions lacking epidemiological data.
一名26岁复发急性单核细胞白血病（AML-M5）的中国男性在巩固化疗期间发生真菌血症。通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）和内转录间隔区（ITS）测序确诊。抗真菌药敏试验显示对棘白菌素耐药，但对两性霉素B敏感。连续监测（1,3）-β-D-葡聚糖与疾病进展相关。该病例凸显了在缺乏流行病学数据地区的诊断挑战和治疗困境。
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