持续保持较高的生命必需8项指标与较低的脑小血管病风险相关：一项基于社区的研究。
Sustained high Life's Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study.
作者信息
Shi Huijing, Cui Liufu, Hui Ying, Shu Rong, Song Haicheng, Wang Jierui, Yu Ping, Chen Shuohua, Li Jing, Liang Xiaoliang, Ruan Chunyu, Chen Jing, Wang Zhenchang, Wu Shouling, Li Xiaoshuai
机构信息
Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, China.
Department of Radiology, Kailuan General Hospital, Tangshan, China.
出版信息
Front Neurol. 2025 Jul 9;16:1563288. doi: 10.3389/fneur.2025.1563288. eCollection 2025.
OBJECTIVE
We aimed to investigate the influence of Life's Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).
METHODS
A total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory modeling of the SAS procedure Proc Traj. Participants were classified into three trajectory models: low stable group, medium stable group, and high stable group. Magnetic resonance imaging (MRI) was performed at the last follow-up. Ordered logistic regression and binary logistic regression models were employed to analyze the association between LE8 trajectory groups and the total CSVD score. Furthermore, we examined the relationship between LE8 trajectory groups and Various CSVD Lesions: lacunar infarcts, cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS).
RESULTS
(1) There is a negative association between sustained high LE8 scores and the risk of CSVD. The odds ratios (OR) for an increased risk of elevated CSVD scores in the medium and high stable groups compared to the low stable group were 0.65 (95% CI: 0.47-0.88) and 0.44 (95% CI: 0.30-0.63), both of which were statistically significant. (2) LE8 had the most significant impact on lacunar infarcts, EPVS and WMH. The ORs for an increased risk of lacunar infarcts in the medium and high stable groups compared to the low stable group were 0.56 (95% CI: 0.37-0.86) and 0.25 (95% CI: 0.14-0.47), respectively. The ORs for an increased risk of BG-EPVS were 0.49 (95% CI: 0.30-0.81) and 0.31 (95% CI: 0.18-0.54), respectively. The ORs for an increased risk of WMH were 0.49 (95% CI: 0.64-1.38) and 0.58 (95% CI: 0.36-0.95), respectively. However, LE8 showed no statistically significant impact on CMB.
CONCLUSION
In summary, our study revealed that sustained high Life's Essential 8 scores have a protective effect against cerebral small vessel disease.
目的
我们旨在研究生命基本8要素（LE8）评分轨迹对脑小血管病（CSVD）的影响。
方法
共纳入了开滦前瞻性队列研究中的1162名受试者。使用SAS程序Proc Traj的轨迹建模方法得出了2006年至2021年的LE8评分轨迹。参与者被分为三个轨迹模型：低稳定组、中稳定组和高稳定组。在最后一次随访时进行了磁共振成像（MRI）检查。采用有序逻辑回归和二元逻辑回归模型分析LE8轨迹组与CSVD总评分之间的关联。此外，我们还研究了LE8轨迹组与各种CSVD病变之间的关系：腔隙性梗死、脑微出血（CMB）、白质高信号（WMH）和血管周围间隙增宽（EPVS）。
结果
（1）持续高LE8评分与CSVD风险之间存在负相关。与低稳定组相比，中稳定组和高稳定组CSVD评分升高风险的优势比（OR）分别为0.65（95%CI：0.47 - 0.88）和0.44（95%CI：0.30 - 0.63），两者均具有统计学意义。（2）LE8对腔隙性梗死、EPVS和WMH的影响最为显著。与低稳定组相比，中稳定组和高稳定组腔隙性梗死风险增加的OR分别为0.56（95%CI：0.37 - 0.86）和分别为0.25（95%CI：0.14 - 0.47）。BG - EPVS风险增加的OR分别为0.49（95%CI：0.30 - 0.81）和0.31（95%CI：0.18 - 0.54）。WMH风险增加的OR分别为0.49（95%CI：0.64 - 1.38）和0.58（95%CI：0.36 - 0.95）。然而，LE8对CMB没有统计学上的显著影响。
结论
总之，我们的研究表明，持续高的生命基本8要素评分对脑小血管病具有保护作用。
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