Jiang Yang, Su Zhen, Zheng Jing, Hsu Chih-Hung, Chen Ye
Department of Genetic and Metabolic Disease, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310003, China.
College of Life Sciences, Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Zhejiang University, Hangzhou 310058, China.
J Zhejiang Univ Sci B. 2025 Jul 15;26(7):613-632. doi: 10.1631/jzus.B2500166.
The zebrafish has emerged as a powerful model organism in life science owing to its remarkable biological characteristics and wide-ranging applications. This review provides a comprehensive overview of the recent advancements in research on zebrafish within the field of environmental toxicology, highlighting specific studies where this species was used to investigate various pollutants to elucidate their impacts and underlying mechanisms. The findings of these studies underscore the significant potential of zebrafish as a model to gain crucial insights into the ecological consequences of environmental contamination and toxicity pathways. By incorporating cutting-edge technologies such as artificial intelligence (AI), high-throughput screening, and omics approaches, the use of zebrafish as a model organism is poised to significantly accelerate toxicological investigations, promote environmental conservation efforts, contribute to safeguarding human health, and advance sustainable development objectives.
由于其显著的生物学特性和广泛的应用,斑马鱼已成为生命科学中一种强大的模式生物。本综述全面概述了环境毒理学领域内斑马鱼研究的最新进展,重点介绍了利用该物种研究各种污染物以阐明其影响和潜在机制的具体研究。这些研究结果强调了斑马鱼作为一种模型的巨大潜力,可用于深入了解环境污染的生态后果和毒性途径。通过整合人工智能(AI)、高通量筛选和组学方法等前沿技术,将斑马鱼用作模式生物有望显著加速毒理学研究,促进环境保护工作,为保障人类健康做出贡献,并推动可持续发展目标的实现。