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Medical College, Hunan University of Chinese Medicine, Changsha 410208, China.
College of Acupuncture and Moxibustion, Hunan University of Chinese Medicine, Changsha 410208, China.
Biomolecules. 2025 Jul 5;15(7):970. doi: 10.3390/biom15070970.
Breast cancer is the leading threat to the health of women, with a rising global incidence linked to social and psychological factors. Among its subtypes, triple-negative breast cancer (TNBC), which lacks , , and expression, is highly heterogeneous with early metastasis and a poor prognosis, making it the most challenging subtype. Mounting evidence shows that the mitochondrial quality control (MQC) system is vital for maintaining cellular homeostasis. Dysfunction of the MQC is tied to tumor cell invasiveness, metastasis, and chemoresistance. This paper comprehensively reviews the molecular link between MQC and TNBC development. We focused on how abnormal MQC affects TNBC progression by influencing chemoresistance, immune evasion, metastasis, and cancer stemness. On the basis of current studies, new TNBC treatment strategies targeting key MQC nodes have been proposed. These findings increase the understanding of TNBC pathogenesis and offer a theoretical basis for overcoming treatment challenges, providing new research angles and intervention targets for effective precision therapy for TNBC.
乳腺癌是对女性健康的主要威胁，全球发病率上升与社会和心理因素有关。在其亚型中，三阴性乳腺癌（TNBC）缺乏 、 和 表达，具有高度异质性，早期转移且预后不良，是最具挑战性的亚型。越来越多的证据表明，线粒体质量控制（MQC）系统对于维持细胞稳态至关重要。MQC功能障碍与肿瘤细胞的侵袭性、转移和化疗耐药性有关。本文全面综述了MQC与TNBC发生发展之间的分子联系。我们重点关注了异常的MQC如何通过影响化疗耐药性、免疫逃逸、转移和癌症干性来影响TNBC的进展。基于当前的研究，已经提出了针对关键MQC节点的新的TNBC治疗策略。这些发现加深了对TNBC发病机制的理解，为克服治疗挑战提供了理论基础，为TNBC的有效精准治疗提供了新的研究角度和干预靶点。
