Niu Zhen, Yuan Liang, Die Xiaohong, Liu Wei
Department of General and Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.
Sci Rep. 2025 Jul 29;15(1):27646. doi: 10.1038/s41598-025-11940-9.
This study aims to retrospectively analyze the clinical data of children diagnosed with vascular malformations associated with limb hypertrophy, treated at the General Surgery department of Liangjiang Branch of the Children's Hospital Affiliated to Chongqing Medical University. Additionally, it seeks to explore the diagnostic and therapeutic value of endovascular interventions for this condition. This study conducts a retrospective analysis of the medical records of children with vascular malformations accompanied by limb hypertrophy who received treatment in our department. We summarize their medical history characteristics, clinical manifestations, auxiliary examinations, DSA (Digital Subtraction Angiography) results, intraoperative treatment methods, and follow-up data collected at least 1 year post-surgery to evaluate the diagnostic and therapeutic value of these interventions. This study included a total of 19 children, comprising 10 females and 9 males. The average age was 4 years, while the median age was 3 years and 1 month. The primary site of onset was the lower extremities. The disease types predominantly included arteriovenous malformation (AVM), Klippel-Trenaunay syndrome (KTs), and Parkes-Weber syndrome (PWs). All children underwent digital subtraction angiography (DSA) surgery. During the operation, they were categorized into high-flow and low-flow groups based on their blood flow characteristics, and distinct treatment plans were implemented for each group. Postoperative follow-up revealed a significant decrease in limb skin temperature in the high-flow group before and after treatment (t = 9.266, p = 0.000), while the limb circumference in the low-flow group also decreased significantly (t = 5.701, p = 0.002). Additionally, differences were observed in the relief of symptoms such as limb limping, skin plaques, pain, and pruritus between the two groups. During the postoperative follow-up period, only one child with AVM experienced recanalization 1 year after the operation and subsequently underwent reoperation. Vascular malformations associated with limb hypertrophy are relatively rare in clinical practice. Therefore, it is essential to enhance our understanding of these conditions to facilitate early diagnosis and treatment. Endovascular interventional therapy offers significant advantages for the diagnosis and treatment of this disease, making it worthy of wider adoption in clinical settings. Furthermore, treatment plans should be tailored to the specific clinical characteristics of each patient.
本研究旨在回顾性分析重庆医科大学附属儿童医院两江分院普通外科收治的诊断为伴有肢体肥大的血管畸形患儿的临床资料。此外,探讨血管内介入治疗对该疾病的诊断和治疗价值。本研究对在我科接受治疗的伴有肢体肥大的血管畸形患儿的病历进行回顾性分析。总结其病史特点、临床表现、辅助检查、数字减影血管造影(DSA)结果、术中治疗方法以及术后至少1年收集的随访数据,以评估这些干预措施的诊断和治疗价值。本研究共纳入19例患儿,其中女性10例,男性9例。平均年龄为4岁,中位年龄为3岁1个月。主要发病部位为下肢。疾病类型主要包括动静脉畸形(AVM)、克-特综合征(KTs)和帕克斯-韦伯综合征(PWs)。所有患儿均接受了数字减影血管造影(DSA)手术。术中根据血流特点将其分为高流量组和低流量组,并对每组实施不同的治疗方案。术后随访发现,高流量组治疗前后肢体皮肤温度显著降低(t = 9.266,p = 0.000),而低流量组肢体周径也显著减小(t = 5.701,p = 0.002)。此外,两组在肢体跛行、皮肤斑块、疼痛和瘙痒等症状缓解方面存在差异。术后随访期间,仅1例AVM患儿术后1年出现再通,随后接受了再次手术。伴有肢体肥大的血管畸形在临床实践中相对少见。因此,有必要加强对这些疾病的认识,以利于早期诊断和治疗。血管内介入治疗对该疾病的诊断和治疗具有显著优势,值得在临床中更广泛地应用。此外,治疗方案应根据每个患者的具体临床特点进行定制。