Liu Zongyu, Wang Min, Lei Yuanyuan, Xu Kaiqi, Fan Limei
Department of Surgery, The Second Hospital of Jilin University, Changchun, China.
Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.
Front Microbiol. 2025 Jul 15;16:1606001. doi: 10.3389/fmicb.2025.1606001. eCollection 2025.
Premature ovarian failure is a prevalent gynecological endocrine disorder with an increasing incidence rate each year, impacting women's physical and mental health. The causes of POF are poorly understood, but genetic, immune, iatrogenic, environmental, and psychological factors are key contributors. Clinically, POF manifests as oligomenorrhea, amenorrhea, elevated follicle-stimulating hormone (FSH) levels, and decreased estrogen levels, leading to infertility in women. POF not only impacts reproductive function but also elevates the risk of cardiovascular diseases, osteoporosis, depression, anxiety, cognitive decline, and neurological disorders, thereby adversely affecting women's mental health and quality of life over the long term. The gut microbiota (GM) comprises a vast and complex microbial community within the human gastrointestinal tract. GM dysregulation is closely associated with numerous human diseases, including autoimmune diseases, allergic disorders, cardiovascular diseases, cancers, and metabolic disorders. Studies have shown that GMs play a pivotal role in female reproductive health, participating in the pathogenesis of reproductive endocrine disorders through direct or indirect involvement in sex hormone regulation, stimulation of inflammatory cytokine production, modulation of immune function, metabolic homeostasis, and regulation of neurotransmitter synthesis. Recently, advancements in human microbiology have highlighted the significant interest in the connection between POF and the gut microbiome. Researching the molecular mechanisms by which GMs and their metabolites regulate the occurrence of POF opens up a new direction for studying the pathogenesis of POF. This research aims to identify an efficient, non-invasive, and accurate diagnostic method for clinical diagnosis and treatment of POF, providing novel theoretical insights and precise intervention strategies for the clinical prevention and treatment of POF.
卵巢早衰是一种常见的妇科内分泌疾病，其发病率逐年上升，影响着女性的身心健康。卵巢早衰的病因尚不清楚，但遗传、免疫、医源性、环境和心理因素是主要原因。临床上，卵巢早衰表现为月经过少、闭经、促卵泡生成素（FSH）水平升高和雌激素水平降低，导致女性不孕。卵巢早衰不仅影响生殖功能，还会增加心血管疾病、骨质疏松症、抑郁症、焦虑症、认知能力下降和神经紊乱的风险，从而长期对女性的心理健康和生活质量产生不利影响。肠道微生物群（GM）是人类胃肠道内一个庞大而复杂的微生物群落。GM失调与许多人类疾病密切相关，包括自身免疫性疾病、过敏性疾病、心血管疾病、癌症和代谢紊乱。研究表明，GM在女性生殖健康中起着关键作用，通过直接或间接参与性激素调节、刺激炎性细胞因子产生、调节免疫功能、代谢稳态和调节神经递质合成，参与生殖内分泌紊乱的发病机制。最近，人类微生物学的进展凸显了对卵巢早衰与肠道微生物组之间联系的浓厚兴趣。研究GM及其代谢产物调节卵巢早衰发生的分子机制，为研究卵巢早衰的发病机制开辟了新方向。本研究旨在寻找一种高效、无创、准确的诊断方法，用于卵巢早衰的临床诊断和治疗，为卵巢早衰的临床预防和治疗提供新的理论见解和精确的干预策略。
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