Wang Tao, Tang Xiaoxia, Luo Wen, Chen Ze Hua, Xia Yubo, Zhou Xiaohan, Shu Yang, Lu Chen Yin, Su Wenjie, Chen Qigang, Shen Zhen, Zhou Biao, Luo Zhiqiang
Department of Orthopedics, Kunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Changsha, Kunming, China.
Department of Emergency, Kunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Changsha, Kunming, China.
Medicine (Baltimore). 2025 Aug 1;104(31):e43623. doi: 10.1097/MD.0000000000043623.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction, imposing a significant burden on society. Recent research highlights the critical role of extracellular vesicles (EVs) in RA, but no bibliometric analysis has comprehensively examined this field. This study aims to fill that gap.
Relevant publications from the past 2 decades were retrieved from the Web of Science Core Collection database. Bibliometric analyses were conducted using VOSviewer and the R package "Bibliometrix" to evaluate annual output, collaboration networks, research hotspots, current status, and developmental trends in this field.
A total of 512 publications (311 articles and 201 reviews) from 922 institutions across 59 countries were analyzed. China led in publication volume and citations. Southwest Medical University was the top institution. Frontiers in Immunology published the highest number of publications (35) and received the most citations (1042). The most productive author was LIU Y (13 papers), and the most cited was GAY S (141 citations). Keyword and paper bibliometric analyses revealed revealed 2 major focuses: the role of EVs in RA pathogenesis and therapeutic strategies. High-frequency keywords such as "dendritic cells," "T-cells," and "microRNAs" highlight the involvement of immune cell-derived EVs in RA pathogenesis. While terms like "stem cells" and "mesenchymal stem cells" suggest growing interest in their immunomodulatory potential.
This study represents the first bibliometric analysis of the relationship between RA and EVs. By objectively summarizing the current literature, this work provides insights into the roles of EVs in RA and serves as a valuable reference for researchers interested in this field.
类风湿性关节炎（RA）是一种慢性自身免疫性疾病，其特征为滑膜炎症和关节破坏，给社会带来了沉重负担。近期研究凸显了细胞外囊泡（EVs）在类风湿性关节炎中的关键作用，但尚无文献计量分析全面审视该领域。本研究旨在填补这一空白。
从科学网核心合集数据库检索过去20年的相关出版物。使用VOSviewer和R包“Bibliometrix”进行文献计量分析，以评估该领域的年产出、合作网络、研究热点、现状和发展趋势。
共分析了来自59个国家922个机构的512篇出版物（311篇文章和201篇综述）。中国在出版物数量和被引次数方面领先。西南医科大学是排名第一的机构。《免疫学前沿》发表的出版物数量最多（35篇），被引次数也最多（1042次）。发文量最高的作者是刘Y（13篇论文），被引次数最多的是盖伊S（141次被引）。关键词和论文文献计量分析揭示了两个主要重点：细胞外囊泡在类风湿性关节炎发病机制中的作用以及治疗策略。“树突状细胞”“T细胞”和“微小RNA”等高频率关键词突出了免疫细胞衍生的细胞外囊泡在类风湿性关节炎发病机制中的参与。而“干细胞”和“间充质干细胞”等术语表明对其免疫调节潜力的兴趣与日俱增。
本研究是对类风湿性关节炎与细胞外囊泡之间关系的首次文献计量分析。通过客观总结当前文献，本研究深入探讨了细胞外囊泡在类风湿性关节炎中的作用，为该领域的研究人员提供了有价值的参考。
