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小儿I型开放性胫骨骨折:仅用抗生素是否足够?

Paediatric type I open tibia fractures: are antibiotics alone sufficient?

作者信息

Hammond Rory F L, Manoj Nikhil, Bridgens Anna, Monsell Fergal, Singh Abhinav, Gelfer Yael

机构信息

The Royal London Hospital, London, UK.

City St George's University of London, London, UK.

出版信息

Bone Jt Open. 2025 Aug 8;6(8):905-914. doi: 10.1302/2633-1462.68.BJO-2025-0060.R1.

Abstract

AIMS

The conventional management of the soft-tissue component of an open fracture involves emergent debridement. There is, however, evidence that questions this approach in the management of Gustilo-Anderson type I open fractures in paediatric patients. This systematic review aims to explore differences in infection rates between nonoperative management with antibiotics and operative debridement in children with type I open lower limb tibial fractures that do not require surgical fixation.

METHODS

A systematic review following the PRISMA guidelines was conducted. Patients aged under 18 years with Gustilo-Anderson type I open tibia fractures treated with either antibiotics alone or operative debridement were included. Polytrauma patients and those requiring operative fracture stabilization were excluded. Study bias was assessed with the ROBINS-I (Risk of Bias in Non-randomized Studies of Interventions) tool.

RESULTS

Ten retrospective studies of 123 patients with Gustilo-Anderson type I open tibial fractures were included. Nonoperative management in the emergency department with antibiotics was used in 41 patients, with two infections reported (4.87%). Operative debridement was performed in 82 patients, with two infections reported (2.33%).

CONCLUSION

The optimum management for paediatric Gustilo-Anderson type I open tibia fractures remains unclear. There may be selected cases, with true low-energy injury without operative fixation requirements, which can be managed in the emergency department. However, there is not sufficient high-quality evidence to advocate for regular deviation from current guidelines in open tibia fractures in paediatric patients. Decision-making must take into account the energy absorbed, as this factor can be misleading within the current classification system.

摘要

目的

开放性骨折软组织部分的传统处理方法是进行急诊清创。然而,有证据对小儿患者中Gustilo-Anderson I型开放性骨折的这种处理方法提出了质疑。本系统评价旨在探讨对于无需手术固定的I型开放性下肢胫骨骨折患儿,抗生素非手术治疗与手术清创在感染率方面的差异。

方法

按照PRISMA指南进行系统评价。纳入年龄在18岁以下、采用单纯抗生素治疗或手术清创治疗的Gustilo-Anderson I型开放性胫骨骨折患者。排除多发伤患者以及需要手术稳定骨折的患者。使用ROBINS-I(干预性非随机研究中的偏倚风险)工具评估研究偏倚。

结果

纳入了10项对123例Gustilo-Anderson I型开放性胫骨骨折患者的回顾性研究。41例患者在急诊科采用抗生素非手术治疗,报告了2例感染(4.87%)。82例患者进行了手术清创,报告了2例感染(2.33%)。

结论

小儿Gustilo-Anderson I型开放性胫骨骨折的最佳治疗方法仍不明确。对于某些真正低能量损伤且无需手术固定的特定病例,可在急诊科进行处理。然而,目前尚无足够的高质量证据支持小儿开放性胫骨骨折常规偏离现行指南。决策时必须考虑所吸收的能量,因为在当前分类系统中该因素可能会产生误导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e5/12331384/431f64870879/BJO-2025-0060.R1-galleyfig1.jpg

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