Yang Minxia, Xuan Feng, Wang Liejiong, Lou Ying, Yu Shengjian
Department of Radiology, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
Department of Radiation Oncology, Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, Zhejiang, China.
Front Public Health. 2025 Jul 24;13:1602454. doi: 10.3389/fpubh.2025.1602454. eCollection 2025.
This study aimed to investigate the spatial and temporal variations of tracheal, bronchus, and lung cancer (TBLC) attributable to particulate matter pollution across 34 Asian countries and territories from 1990 to 2021.
Disability-adjusted life years (DALYs) linked to ambient particulate-matter pollution (APMP) and household air pollution (HAP) were obtained from the Global Burden of Disease (GBD) 2021 dataset, and performed analyses stratified by location, gender, and age. Trends in age-standardized DALY rates (ASDRs) were quantified with Joinpoint regression. Decomposition analysis was applied to identify the contributions of population aging, population growth, and epidemiological changes to the alterations in DALYs.
From 1990 to 2021, APMP-related ASDR increased significantly in Asia, while HAP-related ASDR declined. In 2021, East Asia recorded the greatest APMP-associated DALYs across five GBD regions, while both South Asia and East Asia bore the heaviest HAP-related burden. China reported the highest absolute DALYs for each pollutant. Population aging and growth accounted for most of the increase in APMP-related DALYs in Asia, whereas epidemiological change chiefly explained the reduction in HAP-related DALYs. ASDRs were consistently higher in males, with wider sex disparities for APMP-related ASDR. Middle-aged and older adult populations were the most vulnerable age groups.
Although TBLC burden attributable to HAP has fallen, disease linked to APMP remains a pressing public-health concern. Coordinated regional action and targeted interventions, particularly for men and older individuals, are essential to reduce pollution-driven TBLC across Asia.
本研究旨在调查1990年至2021年期间，34个亚洲国家和地区因颗粒物污染导致的气管、支气管和肺癌（TBLC）的时空变化。
从《2021年全球疾病负担》（GBD）数据集中获取与环境颗粒物污染（APMP）和家庭空气污染（HAP）相关的伤残调整生命年（DALYs），并按地点、性别和年龄进行分层分析。采用Joinpoint回归对年龄标准化DALY率（ASDRs）的趋势进行量化。应用分解分析来确定人口老龄化、人口增长和流行病学变化对DALYs变化的贡献。
1990年至2021年期间，亚洲与APMP相关的ASDR显著增加，而与HAP相关的ASDR下降。2021年，在全球疾病负担的五个区域中，东亚记录的与APMP相关的DALYs最多，而南亚和东亚都承担着与HAP相关的最重负担。中国报告的每种污染物的绝对DALYs最高。人口老龄化和增长占亚洲与APMP相关的DALYs增加的大部分，而流行病学变化主要解释了与HAP相关的DALYs的减少。男性的ASDRs一直较高，与APMP相关的ASDR的性别差异更大。中年和老年人群是最脆弱的年龄组。
尽管HAP导致的TBLC负担有所下降，但与APMP相关的疾病仍然是紧迫的公共卫生问题。协调区域行动和有针对性的干预措施，特别是针对男性和老年人的措施，对于减少亚洲各地由污染驱动的TBLC至关重要。
