慢性阻塞性肺疾病的肺功能测试与颈动脉内膜中层厚度
Pulmonary function test and carotid intima-media thickness in chronic obstructive pulmonary disease.
作者信息
Sorouri Shahabaddin, Naseri Maryam, Hejazi Sepideh
机构信息
Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Caspian J Intern Med. 2025 Jun 23;16(3):487-492. doi: 10.22088/cjim.16.3.487. eCollection 2025 Summer.
BACKGROUND
Studies have shown that carotid intima-media thickness (CIMT) is an indicator of cardiovascular events and mortality and its increase has correlation with severe airflow obstruction in patients with COPD. The aim of this study was to investigate the association between pulmonary function and CIMT in COPD patients.
METHODS
This study was performed on two groups of patients with and without COPD (cases & controls) who were referred to pulmonary clinics. Demographic, clinical, and laboratory tests were recorded in questionnaire. Spirometry was performed in cases and FVC, FEV1, and FEV1/FVC were measured. CIMT was determined via ultrasound.
RESULTS
Our results indicated that right carotid IMT was 0.51±0.112 mm and 0.65±0.131 mm in the control and case groups, respectively (p< 0.001). Left CIMT was 0.48±0.089 mm and 0.68±0.113 mm in the control and case groups, respectively (p< 0.001). FEV1 and FEV1/FVC had an inverse and significant correlation with IMT of the carotid (both right and left carotid).
CONCLUSION
The results indicated an inverse association between carotid IMT and lung function test in COPD patients.
背景
研究表明，颈动脉内膜中层厚度（CIMT）是心血管事件和死亡率的一个指标，其增加与慢性阻塞性肺疾病（COPD）患者的严重气流阻塞相关。本研究的目的是调查COPD患者肺功能与CIMT之间的关联。
方法
本研究对两组转诊至肺部诊所的患者进行，一组为COPD患者，另一组为非COPD患者（病例组和对照组）。人口统计学、临床和实验室检查结果记录在问卷中。对病例组进行肺量计检查，测量用力肺活量（FVC）、第1秒用力呼气容积（FEV1）和FEV1/FVC。通过超声测定CIMT。
结果
我们的结果表明，对照组和病例组的右侧颈动脉IMT分别为0.51±0.112mm和0.65±0.131mm（p<0.001）。对照组和病例组的左侧CIMT分别为0.48±0.089mm和0.68±0.113mm（p<0.001）。FEV1和FEV1/FVC与颈动脉（右侧和左侧颈动脉）的IMT呈显著负相关。
结论
结果表明，COPD患者的颈动脉IMT与肺功能测试之间存在负相关。
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