Jin Tonghu, Niu Hao, Liu Lan, Yin Yunjian, Zhao Wenbo, Feng Xin, Xu Liuyu, Hess David C, Liu Aihua, Ji Xunming
Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Beijing Institute For Brain Disorders, Beijing, China.
BMJ Open. 2025 Aug 11;15(8):e101350. doi: 10.1136/bmjopen-2025-101350.
A large number of basic and clinical studies have demonstrated that remote ischaemic conditioning (RIC) has neuroprotective effects. Recently, RIC has made gratifying progress in the field of ischaemia stroke treatment. A considerable number of basic and clinical studies have also revealed the possible therapeutic effects of RIC on subarachnoid haemorrhage. However, the neuroprotective effect of RIC on subarachnoid haemorrhage is still lacking convincing evidence and deserves further study.
To explore the efficacy and safety of RIC for aneurysmal subarachnoid haemorrhage.
An investigator-initiated, multicentre, randomised, double-blind, sham-controlled, parallel-group trial to evaluate the effect of RIC intervention compared to sham RIC intervention for the neurological function improvement of patients with aneurysmal subarachnoid haemorrhage.
The protocol was approved by the IRB of Beijing Tiantan Hospital, Capital Medical University (KY2024-080-03). Progress and safety of the trial are monitored by an independent Data and Safety Monitoring Board. Study results will be published in peer-reviewed medical journals. Written informed consent will be obtained from all participants.
NCT06711302.
大量基础和临床研究表明，远程缺血预处理（RIC）具有神经保护作用。近年来，RIC在缺血性脑卒中治疗领域取得了令人满意的进展。相当数量的基础和临床研究也揭示了RIC对蛛网膜下腔出血可能具有的治疗作用。然而，RIC对蛛网膜下腔出血的神经保护作用仍缺乏令人信服的证据，值得进一步研究。
探讨RIC治疗动脉瘤性蛛网膜下腔出血的有效性和安全性。
一项由研究者发起的、多中心、随机、双盲、假对照、平行组试验，旨在评估RIC干预与假RIC干预相比，对动脉瘤性蛛网膜下腔出血患者神经功能改善的效果。
该方案已获得首都医科大学附属北京天坛医院伦理审查委员会批准（KY2024-080-03）。试验的进展和安全性由独立的数据与安全监测委员会进行监测。研究结果将发表在同行评审的医学期刊上。将获得所有参与者的书面知情同意书。
NCT06711302。
