Sakavitsi Viktoria, Fotiadou Renia, Subrati Mohammed, Datta Kasibhatta Kumara Ramanatha, Baroud Turki N, Behera Swarnamayee, Spyrou Konstantinos, Hammami Mohamed A, Zygouri Panagiota, Stamatis Haralambos, Yentekakis Ioannis V, Gournis Dimitrios P
Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110, Greece.
Laboratory of Biotechnology, Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, Greece.
ACS Omega. 2025 Jul 17;10(29):31568-31576. doi: 10.1021/acsomega.5c02154. eCollection 2025 Jul 29.
Synthetic clay analogues (SCAs) of a new organosilicate layered material family, in contrast to common clays, are produced via an in situ room-temperature sol-gel route, providing the possibility for the design and synthesis of diverse, tailor-made functional groups on the surface and interior of the synthetic clay sheets. In this work, we introduce organophyllosilicates bearing different functional end groups, which are synthesized by a magnesium metal salt precursor and organosilanes such as (3-aminopropyl)-triethoxysilane (APTEOS), -[3-(trimethoxysilyl)-propyl]-ethylenediamine (EDAPTEOS), -(3-trimethoxysilylpropyl)-diethylenetriamine (TAPTMOS), 1,4-bis-(triethoxysilyl)-benzene (BTB), tetraethyl orthosilicate (TEOS), 3-glycidoxypropyltrimethoxysilane (GLYMO), and (3-chloropropyl)-trimethoxysilane (CPTMOS). The surface free energy for various organosynthetic clay analogues lies in the 29-252 mJ/m range. SCA's antimicrobial activity was tested against both Gram-negative and Gram-positive bacteria to evaluate the effect of surface functionalization on the viability of these microorganisms. The amino-SCAs displayed higher antibacterial activity compared to epoxy-SCAs, presenting a dose-dependent effect and a structure-dependent motif. Furthermore, Gram-positive bacteria were more susceptible to SCA treatment than Gram-negative.
与普通粘土不同，一种新型有机硅酸盐层状材料家族的合成粘土类似物（SCA）是通过原位室温溶胶 - 凝胶法制备的，这为在合成粘土片层的表面和内部设计和合成各种定制功能基团提供了可能性。在这项工作中，我们介绍了带有不同功能端基的有机叶硅酸盐，它们是由镁金属盐前驱体和有机硅烷如（3 - 氨基丙基） - 三乙氧基硅烷（APTEOS）、 - [3 - （三甲氧基甲硅烷基） - 丙基] - 乙二胺（EDAPTEOS）、 - （3 - 三甲氧基甲硅烷基丙基） - 二亚乙基三胺（TAPTMOS）、1,4 - 双 - （三乙氧基甲硅烷基） - 苯（BTB）、正硅酸四乙酯（TEOS）、3 - 缩水甘油氧基丙基三甲氧基硅烷（GLYMO）和（3 - 氯丙基） - 三甲氧基硅烷（CPTMOS）合成的。各种有机合成粘土类似物的表面自由能在29 - 252 mJ/m范围内。测试了SCA对革兰氏阴性菌和革兰氏阳性菌的抗菌活性，以评估表面功能化对这些微生物生存能力的影响。与环氧 - SCA相比，氨基 - SCA表现出更高的抗菌活性，呈现出剂量依赖性效应和结构依赖性模式。此外，革兰氏阳性菌比革兰氏阴性菌对SCA处理更敏感。
