美国成年人中生命必需的八项因素对听力损失与动脉粥样硬化性心血管疾病之间关联的效应修正作用。

Effect modification by life's essential 8 on the association between hearing loss and atherosclerotic cardiovascular disease among US adults.

作者信息

Li Shujie, Liu Yiping, Xia Shuai, Li Honglin

机构信息

National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Fuwai Central-China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, China.

出版信息

Prev Med Rep. 2025 Jul 27;57:103187. doi: 10.1016/j.pmedr.2025.103187. eCollection 2025 Sep.

DOI:10.1016/j.pmedr.2025.103187

PMID:40791292

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12336650/

Abstract

OBJECTIVE

This study aimed to evaluate whether associations between hearing loss and atherosclerotic cardiovascular disease (ASCVD) were modified by Life's Essential 8 (LE8) in US adults.

METHODS

A total of 10,867 participants from five cycles of the National Health and Nutrition Examination Survey conducted between 2005 and March 2020 were included in the analysis. Multivariable logistic regression models were applied to examine the relationship between hearing loss, LE8, and ASCVD. Interaction analyses were performed to determine whether the association between hearing loss and ASCVD was modified by cardiovascular health.

RESULTS

About half (50.1 %) of the participants were male, with a mean age of 49.2 ± 17.7 years, and 41.3 % white. The weighted prevalence of ASCVD was 9.5 % and audiometry-measured hearing loss was 19.8 %. Hearing loss was independently associated with higher odds of ASCVD (OR 1.44, 95 % CI 1.16, 1.79). Interaction analysis indicated that the association between hearing loss and ASCVD was evident in individuals with low (< 50) or moderate (50-80) LE8 scores, but not in those with high LE8 scores (≥ 80) ( = 0.008).

CONCLUSIONS

This study observed a significant association between hearing loss and ASCVD, with the strength of the association varying across cardiovascular health status.

摘要

目的

本研究旨在评估在美国成年人中，听力损失与动脉粥样硬化性心血管疾病（ASCVD）之间的关联是否会因生命基本八大要素（LE8）而发生改变。

方法

分析纳入了2005年至2020年3月期间进行的五个周期的美国国家健康与营养检查调查中的10,867名参与者。应用多变量逻辑回归模型来研究听力损失、LE8和ASCVD之间的关系。进行交互分析以确定听力损失与ASCVD之间的关联是否会因心血管健康状况而改变。

结果

约一半（50.1%）的参与者为男性，平均年龄为49.2±17.7岁，41.3%为白人。ASCVD的加权患病率为9.5%，听力测定测得的听力损失患病率为19.8%。听力损失与ASCVD的较高发病几率独立相关（比值比1.44，95%置信区间1.16，1.79）。交互分析表明，听力损失与ASCVD之间的关联在LE8得分低（<50）或中等（50 - 80）的个体中明显，但在LE8得分高（≥80）的个体中不明显（P = 0.008）。