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感染性心内膜炎导致肺假性动脉瘤和严重肺动脉瓣反流:一例报告。

Infective endocarditis leading to pulmonary pseudoaneurysm and severe pulmonary valve regurgitation: A case report.

作者信息

Yin Qin, An Qi

机构信息

Department of Anesthesiology, West China Hospital, Sichuan University/West China School of Nursing, Chengdu, Sichuan, China.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Medicine (Baltimore). 2025 Aug 8;104(32):e43910. doi: 10.1097/MD.0000000000043910.

DOI:10.1097/MD.0000000000043910
PMID:40797426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12338133/
Abstract

RATIONALE

Pulmonary pseudoaneurysm resulting from infective endocarditis is a rare complication in patients with congenital heart disease who have undergone conduit placement.

PATIENT CONCERNS

In this article, we report a rare case of late-onset bacterial infective endocarditis complicated by a pseudoaneurysm and severe pulmonary valve regurgitation in a 16-year-old girl with double-outlet right ventricle, ventricular septal defect, and pulmonary stenosis, who had previously undergone a Rastelli procedure at age 15.

DIAGNOSES

Based on the patient's medical history and transthoracic echocardiography examinations and cardiac computed tomography angiography, a definitive diagnosis of late-onset bacterial infective endocarditis complicated by a pseudoaneurysm and severe pulmonary valve regurgitation was established.

INTERVENTIONS

Given the patient's worsening clinical condition, surgery for ventricular septal defect closure, placement of a new right-ventricle-to-pulmonary-artery conduit with a Gore-tex conduit was conducted.

OUTCOMES

The surgical procedure was successful. The patient was extubated 3 hours postoperatively and received 6 weeks of antibiotic therapy postoperatively, during which no further episodes of fever occurred, and the inflammatory markers decreased to normal levels.

LESSONS

For bacterial infective endocarditis associated with pulmonary pseudoaneurysm and severe pulmonary valve regurgitation, early surgical intervention is essential to mitigate further cardiac dysfunction and improve clinical outcomes.

摘要

原理

感染性心内膜炎导致的肺假性动脉瘤是接受管道置入的先天性心脏病患者中罕见的并发症。

患者情况

在本文中,我们报告了一例罕见病例,一名16岁患有右心室双出口、室间隔缺损和肺动脉狭窄的女孩,曾在15岁时接受过Rastelli手术,发生了迟发性细菌性感染性心内膜炎,并发假性动脉瘤和严重肺动脉瓣反流。

诊断

根据患者的病史、经胸超声心动图检查和心脏计算机断层血管造影,确诊为迟发性细菌性感染性心内膜炎,并发假性动脉瘤和严重肺动脉瓣反流。

干预措施

鉴于患者临床状况恶化,进行了室间隔缺损闭合手术,并使用Gore-tex管道置入了一条新的右心室至肺动脉管道。

结果

手术成功。患者术后3小时拔管,术后接受了6周的抗生素治疗,在此期间未再出现发热,炎症指标降至正常水平。

经验教训

对于与肺假性动脉瘤和严重肺动脉瓣反流相关的细菌性感染性心内膜炎,早期手术干预对于减轻进一步的心脏功能障碍和改善临床结果至关重要。

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本文引用的文献

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Perivalvular Extension of Infective Endocarditis After Transcatheter Aortic Valve Replacement.经导管主动脉瓣置换术后感染性心内膜炎的瓣周延伸。
Clin Infect Dis. 2022 Sep 10;75(4):638-646. doi: 10.1093/cid/ciab1004.
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Pseudoaneurysm of the sinus of Valsalva caused by infective endocarditis in a 7-year-old child with congenital heart disease.先天性心脏病 7 岁儿童感染性心内膜炎致主动脉窦假性动脉瘤。
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儿童感染性心内膜炎:2015年更新:美国心脏协会科学声明
Circulation. 2015 Oct 13;132(15):1487-515. doi: 10.1161/CIR.0000000000000298. Epub 2015 Sep 15.
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Infective endocarditis in children with congenital heart disease: cumulative incidence and predictors.先天性心脏病儿童感染性心内膜炎:累积发生率及预测因素。
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J Thorac Cardiovasc Surg. 2013 Sep;146(3):506-11. doi: 10.1016/j.jtcvs.2012.12.001. Epub 2013 Jan 9.
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Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines.美国儿童医院心内膜炎住院治疗趋势:2007 年美国心脏协会抗生素预防指南的影响。
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Pulmonary artery pseudoaneurysm: etiology, presentation, diagnosis, and treatment.肺动脉假性动脉瘤:病因、表现、诊断及治疗
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Mesenteric pseudoaneurysm and cerebral stroke as sequelae of infective endocarditis in an adolescent.一名青少年因感染性心内膜炎出现肠系膜假性动脉瘤和脑卒中等后遗症。
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