Segin Chandran Aardra Binithadas, Pandiar Deepak, Krishnan Reshma Poothakulath, Gopinath Divya
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Front Oral Health. 2025 Jul 30;6:1632316. doi: 10.3389/froh.2025.1632316. eCollection 2025.
Head and neck squamous cell carcinoma (HNSCC) is a group of heterogeneous malignancies and constitutes one of the most prevalent forms of cancer. Oral metronomic chemotherapy (OMCT) is a treatment in which low doses of anticancer drugs are given at regular intervals over a long time, with many advantages over conventional therapies, particularly in nations with high cancer burden. The present systematic review aimed to evaluate the efficacy of OMCT in the management of HNSCC in comparison to other standard chemotherapy regimens. Methodology: The review was registered in the Prospero database (CRD42023426000). An electronic search was conducted using PubMed, Scopus, Web of Science and Google Scholar databases. Articles in which OMCT was used to treat HNSCC were included for systematic review, and the survival and response rates were analyzed.
Twenty-four eligible articles were included for evaluation, which revealed that administration of OMCT produced higher survival and response rates in subjects compared to standard chemotherapy.
The evidence from the included studies supports that oral metronomic chemotherapy is substantially more effective as compared to standard chemotherapy regimens in squamous cell carcinomas of the head and neck.
https://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000, identifier (CRD42023426000).
头颈部鳞状细胞癌（HNSCC）是一组异质性恶性肿瘤，是最常见的癌症形式之一。口服节拍化疗（OMCT）是一种长期定期给予低剂量抗癌药物的治疗方法，与传统疗法相比有许多优势，特别是在癌症负担高的国家。本系统评价旨在评估OMCT与其他标准化疗方案相比在HNSCC治疗中的疗效。方法：该评价已在国际前瞻性系统评价注册库（Prospero数据库，注册号：CRD42023426000）注册。使用PubMed、Scopus、Web of Science和谷歌学术数据库进行电子检索。纳入使用OMCT治疗HNSCC的文章进行系统评价，并分析生存率和缓解率。
纳入24篇符合条件的文章进行评估，结果显示与标准化疗相比，OMCT治疗的患者生存率和缓解率更高。
纳入研究的证据支持，在头颈部鳞状细胞癌中，口服节拍化疗比标准化疗方案有效得多。
https://www.crd.york.ac.uk/PROSPERO/view/CRD42023426000，标识符（CRD42023426000）。
