组织转谷氨酰胺酶免疫球蛋白A升高：乳糜泻还是多型性浆细胞增多症？
Elevated tissue transglutaminase immunoglobulin A: Celiac disease or polytypic plasmacytosis?
作者信息
Turunen Andrew, Ahmed Aisha, Thrush Philip, North Paula, Chugh Ankur
机构信息
Medical College of Wisconsin Milwaukee Wisconsin USA.
Department of Pediatrics, Division of Pediatric Immunology Ann & Robert H Lurie Children's Hospital of Chicago Chicago Illinois USA.
出版信息
JPGN Rep. 2025 Jun 2;6(3):312-315. doi: 10.1002/jpr3.70037. eCollection 2025 Aug.
We report a case of an adolescent girl post cardiac transplant with hypergammaglobulinemia and presumed celiac disease (CD), who had a persistently elevated anti-tissue transglutaminase immunoglobulin A despite a gluten free diet. Refractory CD and Crohn's disease were excluded. Concomitant dairy elimination led to normalization of celiac titers but no histological improvement. Ultimately, she was diagnosed with polytypic plasmacytosis from suspected immune dysregulation.
我们报告了一例心脏移植术后的青春期女孩，她患有高球蛋白血症且疑似患有乳糜泻（CD），尽管采用了无麸质饮食，但其抗组织转谷氨酰胺酶免疫球蛋白A水平持续升高。排除了难治性CD和克罗恩病。同时消除乳制品摄入使乳糜泻滴度恢复正常，但组织学上没有改善。最终，她被诊断为疑似免疫失调导致的多型性浆细胞增多症。
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