Zhang Yining, Wu Jinfa, Liu Jiaming
Department of Orthopaedic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, PR China.
The First Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, PR China.
Cancer Gene Ther. 2025 Aug 16. doi: 10.1038/s41417-025-00952-2.
Long non-coding RNAs (lncRNAs) have attracted significant attention for their role in tumor initiation and progression. Specifically, studying lncRNA small nucleolar RNA host genes (lncSNHGs) has opened up new possibilities for the treatment of osteosarcoma (OS). This review aims to give a thorough overview of the state of research on the biological roles, molecular mechanisms, and expression of the lncRNA SNHG family in OS. Through an extensive analysis, it is demonstrated that members of the SNHG family exhibit dysregulated expression patterns in OS. These dysregulations affect multiple oncogenic processes, including tumor proliferation, metastasis, apoptosis, autophagy, and chemotherapy resistance. The lncRNA SNHG family promises to identify novel strategies and targets for diagnosing, treating, and prognosis OS.
长链非编码RNA(lncRNAs)因其在肿瘤发生和进展中的作用而备受关注。具体而言,对长链非编码RNA小核仁RNA宿主基因(lncSNHGs)的研究为骨肉瘤(OS)的治疗开辟了新的可能性。本综述旨在全面概述lncRNA SNHG家族在骨肉瘤中的生物学作用、分子机制和表达的研究现状。通过广泛分析表明,SNHG家族成员在骨肉瘤中表现出表达模式失调。这些失调影响多个致癌过程,包括肿瘤增殖、转移、凋亡、自噬和化疗耐药性。lncRNA SNHG家族有望为骨肉瘤的诊断、治疗和预后确定新的策略和靶点。