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基于重症监护病房撤机困难患者的目标导向性肺康复训练方案效果分析

Analysis of the effects of a goal-oriented pulmonary rehabilitation training program based on patients with ventilator withdrawal difficulties in the ICU.

作者信息

Wang Kaiwen, Dai Shujia

机构信息

The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

出版信息

Medicine (Baltimore). 2025 Aug 15;104(33):e43846. doi: 10.1097/MD.0000000000043846.

Abstract

BACKGROUND

Difficult weaning from mechanical ventilation in ICU patients prolongs hospitalization and increases risks of complications like ventilator-associated pneumonia and ICU-acquired weakness. While standard care (airway management and early functional exercise) is routine, outcomes remain suboptimal. This study evaluated a nurse-led, goal-directed pulmonary rehabilitation program to improve weaning success, reduce weaning time, and enhance physiological/functional recovery in this high-risk population.

METHODS

Using convenience sampling, 70 ICU patients with difficult weaning (admitted August 2023-July 2024) were divided into historical control and observation groups (35 each). The control group (August 2023-January 2024) received standard airway care and early functional exercise. The observation group (February-August 2024) received additional nurse-led pulmonary rehabilitation, including individualized goal setting, progressive respiratory training (using continuous positive airway pressure/synchronized intermittent mandatory ventilation protocols), daily sedation-pain-agitation monitoring (Richmond Agitation-Sedation Scale/Care Pain Observation Tool), and muscle strengthening guided by the ICU Mobility Scale. Outcomes compared included weaning success rate, weaning time, oxygenation index (PaO₂/FiO₂), muscle strength (Medical Research Council scale), and self-care ability (Barthel Index), with statistical significance set at P < .05.

RESULTS

The observation group demonstrated significantly higher weaning success rates and shorter weaning times versus controls (P < .05). While pre-intervention oxygenation indices showed no difference (P > .05), post-intervention PaO₂/FiO₂ ratios were significantly higher in the observation group (P < .05). Muscle strength (Medical Research Council scores) and self-care ability (Barthel Index scores) also showed statistically significant improvements in the intervention group after treatment (P < .05).

CONCLUSION

The nurse-led, goal-directed pulmonary rehabilitation program significantly accelerates weaning, increases success rates, and improves oxygenation, muscle strength, and self-care ability in difficult-to-wean ICU patients. It represents an effective enhancement to standard care and is recommended for broader clinical implementation.

摘要

背景

重症监护病房(ICU)患者机械通气撤机困难会延长住院时间,并增加呼吸机相关性肺炎和ICU获得性肌无力等并发症的风险。虽然标准护理(气道管理和早期功能锻炼)是常规操作,但结果仍不尽人意。本研究评估了一项由护士主导的、目标导向的肺康复计划,以提高撤机成功率、缩短撤机时间,并促进这一高危人群的生理/功能恢复。

方法

采用便利抽样法,将70例撤机困难的ICU患者(2023年8月至2024年7月入院)分为历史对照组和观察组(每组35例)。对照组(2023年8月至2024年1月)接受标准气道护理和早期功能锻炼。观察组(2024年2月至8月)接受额外的由护士主导的肺康复治疗,包括个性化目标设定、渐进性呼吸训练(使用持续气道正压通气/同步间歇指令通气方案)、每日镇静-疼痛-躁动监测(使用里士满躁动-镇静量表/护理疼痛观察工具),以及根据ICU活动量表进行肌肉强化训练。比较的结果包括撤机成功率、撤机时间、氧合指数(PaO₂/FiO₂)、肌肉力量(医学研究委员会量表)和自理能力(Barthel指数),设定P<0.05为具有统计学意义。

结果

与对照组相比,观察组的撤机成功率显著更高,撤机时间显著更短(P<0.05)。虽然干预前氧合指数无差异(P>0.05),但干预后观察组的PaO₂/FiO₂比值显著更高(P<0.05)。治疗后,干预组的肌肉力量(医学研究委员会评分)和自理能力(Barthel指数评分)也有统计学意义的改善(P<0.05)。

结论

由护士主导的、目标导向的肺康复计划显著加速了撤机过程,提高了成功率,并改善了撤机困难的ICU患者的氧合、肌肉力量和自理能力。它是对标准护理的有效补充,建议在更广泛的临床中实施。

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