Wang Kaiwen, Dai Shujia
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Medicine (Baltimore). 2025 Aug 15;104(33):e43846. doi: 10.1097/MD.0000000000043846.
Difficult weaning from mechanical ventilation in ICU patients prolongs hospitalization and increases risks of complications like ventilator-associated pneumonia and ICU-acquired weakness. While standard care (airway management and early functional exercise) is routine, outcomes remain suboptimal. This study evaluated a nurse-led, goal-directed pulmonary rehabilitation program to improve weaning success, reduce weaning time, and enhance physiological/functional recovery in this high-risk population.
Using convenience sampling, 70 ICU patients with difficult weaning (admitted August 2023-July 2024) were divided into historical control and observation groups (35 each). The control group (August 2023-January 2024) received standard airway care and early functional exercise. The observation group (February-August 2024) received additional nurse-led pulmonary rehabilitation, including individualized goal setting, progressive respiratory training (using continuous positive airway pressure/synchronized intermittent mandatory ventilation protocols), daily sedation-pain-agitation monitoring (Richmond Agitation-Sedation Scale/Care Pain Observation Tool), and muscle strengthening guided by the ICU Mobility Scale. Outcomes compared included weaning success rate, weaning time, oxygenation index (PaO₂/FiO₂), muscle strength (Medical Research Council scale), and self-care ability (Barthel Index), with statistical significance set at P < .05.
The observation group demonstrated significantly higher weaning success rates and shorter weaning times versus controls (P < .05). While pre-intervention oxygenation indices showed no difference (P > .05), post-intervention PaO₂/FiO₂ ratios were significantly higher in the observation group (P < .05). Muscle strength (Medical Research Council scores) and self-care ability (Barthel Index scores) also showed statistically significant improvements in the intervention group after treatment (P < .05).
The nurse-led, goal-directed pulmonary rehabilitation program significantly accelerates weaning, increases success rates, and improves oxygenation, muscle strength, and self-care ability in difficult-to-wean ICU patients. It represents an effective enhancement to standard care and is recommended for broader clinical implementation.
重症监护病房(ICU)患者机械通气撤机困难会延长住院时间,并增加呼吸机相关性肺炎和ICU获得性肌无力等并发症的风险。虽然标准护理(气道管理和早期功能锻炼)是常规操作,但结果仍不尽人意。本研究评估了一项由护士主导的、目标导向的肺康复计划,以提高撤机成功率、缩短撤机时间,并促进这一高危人群的生理/功能恢复。
采用便利抽样法,将70例撤机困难的ICU患者(2023年8月至2024年7月入院)分为历史对照组和观察组(每组35例)。对照组(2023年8月至2024年1月)接受标准气道护理和早期功能锻炼。观察组(2024年2月至8月)接受额外的由护士主导的肺康复治疗,包括个性化目标设定、渐进性呼吸训练(使用持续气道正压通气/同步间歇指令通气方案)、每日镇静-疼痛-躁动监测(使用里士满躁动-镇静量表/护理疼痛观察工具),以及根据ICU活动量表进行肌肉强化训练。比较的结果包括撤机成功率、撤机时间、氧合指数(PaO₂/FiO₂)、肌肉力量(医学研究委员会量表)和自理能力(Barthel指数),设定P<0.05为具有统计学意义。
与对照组相比,观察组的撤机成功率显著更高,撤机时间显著更短(P<0.05)。虽然干预前氧合指数无差异(P>0.05),但干预后观察组的PaO₂/FiO₂比值显著更高(P<0.05)。治疗后,干预组的肌肉力量(医学研究委员会评分)和自理能力(Barthel指数评分)也有统计学意义的改善(P<0.05)。
由护士主导的、目标导向的肺康复计划显著加速了撤机过程,提高了成功率,并改善了撤机困难的ICU患者的氧合、肌肉力量和自理能力。它是对标准护理的有效补充,建议在更广泛的临床中实施。