Palma-Lozano Diana, Tapia-Sequeiros Gustavo, Uribe-Cavero Leonardo J, Ñaña-Cordova Alvaro M, Roman-Lazarte Victor
Universidad de Huanuco, Peru.
Universidad Privada de Tacna, Peru.
Sage Open Pediatr. 2025 Aug 16;12:30502225251361989. doi: 10.1177/30502225251361989. eCollection 2025 Jan-Dec.
The development of pubertal characteristics may be influenced by exogenous factors, including endocrine disruptors. Phytoestrogens, plant-derived compounds with estrogenic activity, have been studied for their potential impact on pubertal timing. This scoping review assessed the available evidence on the association between dietary phytoestrogen consumption and early pubertal development. A systematic search of 5 databases identified 16 studies: 1 clinical trial, 3 experimental animal studies, and 12 observational studies. Study designs and methodological quality were heterogeneous. Prospective cohort studies, offering higher-quality evidence, reported an inverse association between phytoestrogen intake and early pubertal development, while cross-sectional studies of lower quality found a direct association. Although findings are inconsistent, the best-quality evidence suggests that phytoestrogen consumption may delay pubertal onset. Further research with robust designs and standardized measures is required to clarify this relationship.
青春期特征的发育可能受到包括内分泌干扰物在内的外源性因素的影响。植物雌激素是具有雌激素活性的植物衍生化合物，人们已经对其对青春期时间的潜在影响进行了研究。本综述评估了饮食中植物雌激素摄入量与青春期早期发育之间关联的现有证据。对5个数据库进行系统检索后确定了16项研究：1项临床试验、3项实验动物研究和12项观察性研究。研究设计和方法学质量各不相同。提供更高质量证据的前瞻性队列研究报告称，植物雌激素摄入量与青春期早期发育呈负相关，而质量较低的横断面研究则发现呈正相关。尽管研究结果不一致，但质量最佳的证据表明，食用植物雌激素可能会延迟青春期开始。需要采用更可靠的设计和标准化测量方法进行进一步研究，以阐明这种关系。
