Abukhalid Norah, Alzahrani Nabeel, Alsager Khaled, Alsowailmi Banan, Albawardi Amjad
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
J Clin Tuberc Other Mycobact Dis. 2025 Jul 26;41:100554. doi: 10.1016/j.jctube.2025.100554. eCollection 2025 Dec.
We present a case series of six children who were infected with different species of Nontuberculous mycobacteria (NTM) and was the most prevalent isolate representing 50% of the total pathogens. Four of the reported cases were immunocompromised with disseminated NTM diseases and two were infected with , , and the other two infected with . Most patients responded to medical therapy, except for the case, which was fatal despite combination therapy. Due to the presence of mycolic acid in the cell wall of NTM isolates, prolonged combination therapy is required for treatment, and in some cases, natural resistance may also emerge. Most of the patients reported in our study were immunocompetent. This suggests that NTM can infect children at various body sites regardless of immune status. We highlighted our experience in diagnosing and treating these patients, with special attention to .
我们报告了一组6例感染不同种类非结核分枝杆菌（NTM）的儿童病例，其中 是最常见的分离株，占总病原体的50%。报告的病例中有4例免疫功能低下，患有播散性NTM疾病，2例感染了 、 ，另外2例感染了 。除了 病例外，大多数患者对药物治疗有反应，该病例尽管采用了联合治疗仍死亡。由于NTM分离株细胞壁中存在分枝菌酸，治疗需要延长联合治疗时间，在某些情况下还可能出现天然耐药性。我们研究中报告的大多数患者免疫功能正常。这表明NTM可感染不同免疫状态的儿童身体的各个部位。我们重点介绍了诊断和治疗这些患者的经验，特别关注 。
