氟碳乳剂（20%）对大鼠皮瓣存活的影响。

Effect of Fluosol-DA (20%) on skin flap survival in rats.

作者信息

Ramasastry S S, Waterman P, Angel M F, Futrell J W

出版信息

Ann Plast Surg. 1985 Nov;15(5):436-42. doi: 10.1097/00000637-198511000-00011.

DOI:10.1097/00000637-198511000-00011

Abstract

This study evaluates the effect of increased oxygen-carrying capacity of blood with the oxygen-carrying blood substitute Fluosol-DA (20%) on skin flap survival in rats. A skin flap model as described by Finseth was used in male Sprague-Dawley rats. We found that Fluosol-DA (20%) alone or in conjunction with O2 does not augment survival of skin flaps in rats, while hemodilution enhances and hemoconcentration deteriorates skin flap survival. Systemic O2 does not enhance survival of skin flaps in rats.

摘要

本研究评估携氧血液代用品氟碳乳剂（20%）增加血液携氧能力对大鼠皮瓣存活的影响。在雄性斯普拉格-道利大鼠中采用了芬塞思所描述的皮瓣模型。我们发现，单独使用氟碳乳剂（20%）或与氧气联合使用均不能提高大鼠皮瓣的存活率，而血液稀释可提高皮瓣存活率，血液浓缩则会降低皮瓣存活率。全身性给氧并不能提高大鼠皮瓣的存活率。