脑室造口术患者美洛西林的脑脊液穿透情况。
Cerebrospinal fluid penetration of moxalactam in ventriculostomy patients.
作者信息
Creger R J, Cowan R I, Nearman H S, Blumer J L, Selman W R, Danziger L H
出版信息
Antimicrob Agents Chemother. 1985 Dec;28(6):839-41. doi: 10.1128/AAC.28.6.839.
Abstract
The cerebrospinal fluid penetration of moxalactam was simultaneously investigated in three patients with presumed bacterial meningitis. When ratios of simultaneously drawn ventriculostomy to serum moxalactam levels of 1, 2, 3, and 4 h were examined, the penetration ratios were 7.8 +/- 2.4, 11.2 +/- 1.3, 14.2 +/- 2.5, and 15.0 +/- 4.9%, respectively. These ratios were not statistically different from the penetration of moxalactam calculated by the area under the concentration-time curve technique (8.97 +/- 1.89%).
摘要
在三名疑似细菌性脑膜炎患者中同时研究了氨曲南的脑脊液穿透情况。当检测同时抽取的脑室引流液与血清中氨曲南在1、2、3和4小时时的水平比值时，穿透率分别为7.8±2.4%、11.2±1.3%、14.2±2.5%和15.0±4.9%。这些比值与通过浓度-时间曲线下面积技术计算出的氨曲南穿透率（8.97±1.89%）无统计学差异。
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2
Computation of model-independent pharmacokinetic parameters during multiple dosing.
J Pharm Sci. 1984 Apr;73(4):570-1. doi: 10.1002/jps.2600730436.
3
Noncompartmental determination of the steady-state volume of distribution during multiple dosing.多次给药期间稳态分布容积的非房室测定
J Pharm Sci. 1984 Feb;73(2):281-2. doi: 10.1002/jps.2600730239.
4
Steady-state moxalactam pharmacokinetics in patients: noncompartmental versus two-compartmental analysis.患者体内稳态莫西拉坦的药代动力学：非房室分析与二房室分析
J Pharmacokinet Biopharm. 1983 Aug;11(4):337-53. doi: 10.1007/BF01058954.
5
Developmental pharmacokinetics of moxalactam.羟羧氧酰胺菌素的发育药代动力学。
Antimicrob Agents Chemother. 1983 Sep;24(3):383-7. doi: 10.1128/AAC.24.3.383.
6
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J Pediatr. 1981 Dec;99(6):975-9. doi: 10.1016/s0022-3476(81)80036-4.
7
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8
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