Gao Xiaobin, Du Shuhua, Zeng Jun, Li Yan, Shen Dan
Ningbo Bo Run Psoriasis Specialized Clinic, Ningbo, China.
Chengdu Yinkang Psoriasis Hospital, Chengdu, China.
Lasers Med Sci. 2025 Aug 22;40(1):342. doi: 10.1007/s10103-025-04599-1.
Plaque psoriasis is an immune-mediated chronic recurrent skin disease. In recent years, 308 nm excimer laser (308 nm EL) and topical tacrolimus have been widely used to treat psoriasis. The purpose of this study was to evaluate the efficacy of 308 nm EL irradiation combined with 0.1% tacrolimus ointment in the treatment of plaque psoriasis. This study was a retrospective observational study involving 100 patients with plaque psoriasis, divided into two groups: the control group (50 cases) was treated with 0.1% tacrolimus ointment; the observation group (50 cases) was treated with 308 nm EL and 0.1% tacrolimus ointment. After eight weeks of treatment, the psoriasis area and severity index (PASI) of the two groups were compared, and the occurrence of adverse reactions during treatment was recorded. Before treatment, there was no significant difference in PASI scores between the two groups (p > 0.05). However, the PASI scores of the two groups were significantly lower after treatment than before treatment, and the PASI scores of the observation group after treatment were lower than those of the control group (p < 0.05). No serious adverse reactions occurred in either group. 308 nm EL irradiation combined with 0.1% tacrolimus ointment could be considered a safe and effective method for the treatment of plaque psoriasis, which can significantly reduce the PASI score and is more effective than the use of 0.1% tacrolimus ointment alone, and it is expected to be popularized in the clinic.
斑块状银屑病是一种免疫介导的慢性复发性皮肤病。近年来，308nm准分子激光（308nm EL）和外用他克莫司已被广泛用于治疗银屑病。本研究的目的是评估308nm EL照射联合0.1%他克莫司软膏治疗斑块状银屑病的疗效。本研究为回顾性观察研究，纳入100例斑块状银屑病患者，分为两组：对照组（50例）采用0.1%他克莫司软膏治疗；观察组（50例）采用308nm EL联合0.1%他克莫司软膏治疗。治疗8周后，比较两组的银屑病面积和严重程度指数（PASI），并记录治疗期间不良反应的发生情况。治疗前，两组PASI评分差异无统计学意义（p＞0.05）。然而，两组治疗后的PASI评分均显著低于治疗前，且观察组治疗后的PASI评分低于对照组（p＜0.05）。两组均未发生严重不良反应。308nm EL照射联合0.1%他克莫司软膏可被认为是一种安全有效的斑块状银屑病治疗方法，可显著降低PASI评分，比单独使用0.1%他克莫司软膏更有效，有望在临床上推广应用。
