代谢功能障碍相关脂肪性肝病与甲状腺癌风险之间的关联：一项全国性队列研究。

Association between metabolic dysfunction-associated steatotic liver disease and the risk of thyroid cancer: a nationwide cohort study.

作者信息

Lee Jeongmin, Kwak Jeongeun, Kim Min-Hee, Lee Seung-Hwan, Cho Jae-Hyoung, Lim Dong-Jun, Lee Jung Min, Chang Sang-Ah, Kim Hun-Sung

机构信息

Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

Korean J Intern Med. 2025 Sep;40(5):813-822. doi: 10.3904/kjim.2025.006. Epub 2025 Aug 26.

DOI:10.3904/kjim.2025.006

PMID:40859805

Abstract

BACKGROUND/AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with various metabolic disorders; however, its relationship with thyroid cancer remains unclear. This study investigated the association between MASLD and the risk of thyroid cancer.

METHODS

This retrospective cohort study used data from the Korean National Health Insurance Service database on individuals who underwent three or more health examinations between January 2002 and December 2015. MASLD was diagnosed using the Hepatic Steatosis Index. Participants were followed up until December 31, 2019, to assess the incidence of newly diagnosed thyroid cancer.

RESULTS

A total of 121,479 individuals were included in this study. In the age- and sex-adjusted analysis, the risk of thyroid cancer was significantly higher in the MASLD group than in the normal group (HR 1.19, 95% CI 1.11-1.29, p < 0.001). Age was a significant effect modifier of the relationship between MASLD and thyroid cancer (p for interaction < 0.05). Among individuals aged 65 years or older, the risk of thyroid cancer was higher in the MASLD group than in the normal group (HR 1.31, 95% CI 1.00-1.72, p = 0.05), whereas in individuals younger than 65 years, MASLD was not associated with thyroid cancer (HR 0.97, 95% CI 0.89-1.04, p = 0.37).

CONCLUSION

This study suggests an association between MASLD and an increased risk of thyroid cancer in older adults. However, further research is needed to determine whether lifestyle modifications, such as weight management, influence thyroid cancer risk in this population.

摘要

背景/目的：代谢功能障碍相关脂肪性肝病（MASLD）与多种代谢紊乱相关；然而，其与甲状腺癌的关系仍不清楚。本研究调查了MASLD与甲状腺癌风险之间的关联。

方法

这项回顾性队列研究使用了韩国国民健康保险服务数据库中2002年1月至2015年12月期间接受过三次或更多次健康检查的个体数据。使用肝脏脂肪变性指数诊断MASLD。对参与者进行随访至2019年12月31日，以评估新诊断甲状腺癌的发病率。

结果

本研究共纳入121,479名个体。在年龄和性别调整分析中，MASLD组甲状腺癌风险显著高于正常组（HR 1.19，95%CI 1.11-1.29，p<0.001）。年龄是MASLD与甲状腺癌关系的显著效应修饰因素（交互作用p<0.05）。在65岁及以上个体中，MASLD组甲状腺癌风险高于正常组（HR 1.31，95%CI 1.00-1.72，p = 0.05），而在65岁以下个体中，MASLD与甲状腺癌无关（HR 0.97，95%CI 0.89-1.04，p = 0.37）。