Murakami Mamoru, Komabashiri Sara, Harada Kae, Shimizu Takaharu, Nishimura Masahiro
Removable Prosthodontics and Implant Dentistry, Advanced Dentistry Center, Kagoshima University Hospital, Kagoshima 890-8544, Japan.
Section of Dental Hygiene, Division of Clinical Technology, Kagoshima University Hospital, Kagoshima 890-8544, Japan.
Dent J (Basel). 2025 Jul 24;13(8):344. doi: 10.3390/dj13080344.
: The criteria for selecting and managing oral moisturizers have yet to be clearly defined. The purpose of this study was to examine the effects of storage temperature and storage time on the pH and oxidation-reduction potential (ORP) of oral moisturizers. : The pH and ORP of 20 commercially available oral moisturizers stored at 37 °C, 25 °C, and 4 °C were measured immediately after opening (0M) and at 1 month (1M), 3 months (3M), and 6 months (6M) post-opening. The data were analyzed using Fisher's exact test based on the critical pH of enamel and dentin, two-way repeated-measures analysis of variance (ANOVA), and Pearson's correlation analysis. : At 0M, 25% of the products had pH values below the critical threshold for enamel, and 75% fell below that for dentin. The distribution of products significantly differed based on critical pH thresholds ( < 0.05). The two-way repeated-measures ANOVA showed that the pH was significantly affected by the storage time ( < 0.05), but not by the storage temperature or its interaction with time. By contrast, ORP was significantly affected by the storage temperature, storage time, and their interaction ( < 0.05). The Pearson's correlation analysis revealed a significant negative correlation between pH and ORP at 4 °C (6M), 25 °C (1M, 3M, 6M), and 37 °C (all time points) ( < 0.05). : Many oral moisturizers exhibit acidic pH values, indicating that products with a pH of 6.7 or higher should be selected. Additionally, to minimize degradation, oral moisturizers should be stored at 4 °C and used within 3 months of opening.
选择和管理口腔保湿剂的标准尚未明确界定。本研究的目的是考察储存温度和储存时间对口腔保湿剂pH值和氧化还原电位（ORP）的影响。
对20种市售口腔保湿剂在37℃、25℃和4℃下储存，在开封后立即（0M）以及开封后1个月（1M）、3个月（3M）和6个月（6M）时测量其pH值和ORP。基于牙釉质和牙本质的临界pH值，使用Fisher精确检验、双向重复测量方差分析（ANOVA）和Pearson相关分析对数据进行分析。
在0M时，25%的产品pH值低于牙釉质的临界阈值，75%低于牙本质的临界阈值。基于临界pH阈值，产品分布存在显著差异（P<0.05）。双向重复测量方差分析表明，pH值受储存时间的显著影响（P<0.05），但不受储存温度或其与时间的相互作用影响。相比之下，ORP受储存温度、储存时间及其相互作用的显著影响（P<0.05）。Pearson相关分析显示，在4℃（6M）、25℃（1M、3M、6M）和37℃（所有时间点）时，pH值与ORP之间存在显著负相关（P<0.05）。
许多口腔保湿剂呈现酸性pH值，表明应选择pH值为6.7或更高的产品。此外，为尽量减少降解，口腔保湿剂应储存在4℃，并在开封后3个月内使用。
