Çiğdem Burhanettin, Gökçe Şeyda Figül
Department of Neurology, Cumhuriyet University School of Medicine, Sivas, Turkey.
Acta Neurol Belg. 2025 Aug 27. doi: 10.1007/s13760-025-02875-z.
Restless legs syndrome (RLS) is a relatively common movement disorder. Epidemiological data on RLS in young adults remain lacking. The objective of the present study was to determine the prevalence of primer RLS among university students comprising young adults.
The study was performed by two neurologists using the face-to-face survey method. A total of 3,047 students were included in the study. First, secondary causes of RLS were excluded by anamnesis. Then, eligible participants were asked to provide demographic data and answer five questions from the 2014 revised international restless legs syndrome study group (IRLSSG) diagnostic criteria; students who answered "yes" to the five questions were considered to have RLS and were invited to the hospital to further exclude secondary causes of RLS using medical data system, neurological examination, and blood tests. The IRLSSG severity scale was applied to measure the severity of the disease.
Primary RLS was detected in 78 students comprising 44 females and 34 males, with a prevalence rate of 2.6%. Sleep disorders were more common in individuals with RLS (p = 0.005), and included difficulty falling asleep and waking up frequently (p = 0.001). Of the 78 students with RLS, 32 had first-degree relatives with RLS (41.02%).
When the secondary causes of RLS, which adversely affects the quality of life, is excluded, the prevalence of primary RLS in among included university students was 2.6%.
不宁腿综合征(RLS)是一种相对常见的运动障碍。关于年轻成年人RLS的流行病学数据仍然缺乏。本研究的目的是确定包括年轻成年人在内的大学生中原发性RLS的患病率。
该研究由两名神经科医生采用面对面调查方法进行。共有3047名学生纳入研究。首先,通过问诊排除RLS的继发性病因。然后,符合条件的参与者被要求提供人口统计学数据,并回答来自2014年修订的国际不宁腿综合征研究组(IRLSSG)诊断标准的五个问题;对这五个问题回答“是”的学生被认为患有RLS,并被邀请到医院,使用医疗数据系统、神经检查和血液检查进一步排除RLS的继发性病因。应用IRLSSG严重程度量表来测量疾病的严重程度。
在78名学生中检测到原发性RLS,其中女性44名,男性34名,患病率为2.6%。睡眠障碍在RLS患者中更为常见(p = 0.005),包括入睡困难和频繁醒来(p = 0.001)。在78名患有RLS的学生中,32名有RLS的一级亲属(41.02%)。
当排除对生活质量有不利影响的RLS继发性病因后,纳入研究的大学生中原发性RLS的患病率为2.6%。