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急性髓系白血病的基因组评估——主要技术与新方法

Genomic Evaluation of AML-Main Techniques and Novel Approaches.

作者信息

Yahya Dinnar, Stoyanova Milena, Hachmeriyan Mari, Levkova Mariya

机构信息

Department of Medical Genetics, Faculty of Medicine, Medical University of Varna, 9000 Varna, Bulgaria.

Laboratory of Medical Genetics, UMHAT "Sv. Marina", 9000 Varna, Bulgaria.

出版信息

J Clin Med. 2025 Aug 11;14(16):5685. doi: 10.3390/jcm14165685.

Abstract

The genetic diversity of acute myeloid leukemia creates a major obstacle for current research and clinical practice. Despite advances in molecular genetic techniques, various omics approaches, and artificial intelligence, developing a universal algorithm to thoroughly assess each clinical case remains difficult. Starting with current recommendations and classifications, this narrative review highlights the most important diagnostic options available today, new opportunities that are emerging, and the challenges in diagnosing and managing this complex disease.

摘要

急性髓系白血病的基因多样性给当前的研究和临床实践带来了重大障碍。尽管分子遗传学技术、各种组学方法和人工智能取得了进展,但开发一种全面评估每个临床病例的通用算法仍然困难重重。从当前的建议和分类入手,这篇叙述性综述重点介绍了当今最重要的诊断选择、正在出现的新机遇以及诊断和管理这种复杂疾病所面临的挑战。

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本文引用的文献

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AML diagnostics in the 21st century: Use of AI.
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Advances in DNA/RNA Sequencing and Their Applications in Acute Myeloid Leukemia (AML).
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