气候变化时期的早期妊娠：孕早期暴露于高温与妊娠第12/13周时胎儿头臀长度缩短有关——一项来自奥地利维也纳的回顾性研究
Early Pregnancy in Times of Climate Change: First-Trimester Heat Exposure Is Associated With Reduction in Fetal Crown-Rump Length in the 12th/13th Week of Gestation-A Retrospective Study From Vienna, Austria.
作者信息
Nindl S, Hartmann B, Fellner J, Kirchengast S
机构信息
Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Clinic Donaustadt, Department of Gynecology and Obstetrics, Vienna, Austria.
出版信息
Am J Hum Biol. 2025 Jul;37(7):e70107. doi: 10.1002/ajhb.70107.
OBJECTIVES
This study focused on the association between fetal crown-rump length (CRL) in the 12th/13th gestational week and the number of 1st trimester heat days to assess the impact of rising temperature on intrauterine growth in early pregnancy.
METHODS
This single-center medical record-based study comprises 10 085 singleton live births (n = 5228; n = 4857) taking place in Vienna, Austria between 2011 and 2019. The sonographic determination of CRL took place routinely during the 12th or 13th gestational week. Linear regression analyses with CRL as the dependent variable and the number of 1st trimester heat days controlled for maternal parameters and the gestational week of CRL measurement were computed for the entire sample and separately by sex.
RESULTS
CRL decreased significantly (p < 0.001) by 0,015 mm on average per heat day in the 1st trimester. Among male fetuses, CRL decreased significantly (p < 0.001) by 0,021 mm, while among female fetuses, only an insignificant decrease was observed.
CONCLUSION
Heat days during the 1st trimester could have a small adverse effect on early fetal growth.
目的
本研究聚焦于妊娠第12/13周时胎儿头臀长（CRL）与孕早期高温天数之间的关联，以评估气温上升对孕早期子宫内生长的影响。
方法
这项基于单中心医疗记录的研究涵盖了2011年至2019年期间在奥地利维也纳发生的10085例单胎活产（n = 5228；n = 4857）。在妊娠第12周或第13周常规进行CRL的超声测定。以CRL为因变量，对整个样本并按性别分别计算了孕早期高温天数，并对产妇参数和CRL测量的孕周进行了控制的线性回归分析。
结果
孕早期每增加一天高温，CRL平均显著下降（p < 0.001）0.015毫米。在男性胎儿中，CRL显著下降（p < 0.001）0.021毫米，而在女性胎儿中，仅观察到不显著的下降。
结论
孕早期的高温天数可能对早期胎儿生长有轻微的不利影响。
Zotero 插件