6-甲氧基二氢血根碱通过提高活性氧水平和激活IRE1/JNK信号通路抑制非小细胞肺癌细胞的增殖。 - Suppr

6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.

作者信息

Qi Xiao, Niu Chong, Zhang Zi-Zheng, Chen Meng-Ru, Wang Feng-Ze, Fei Hong-Rong

机构信息

School of Pharmacy (Institute of Pharmaceutical Research), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.

School of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, PR China.

出版信息

Cell Biochem Biophys. 2025 Aug 29. doi: 10.1007/s12013-025-01850-y.

DOI:10.1007/s12013-025-01850-y

PMID:40879881

Abstract

摘要

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6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.

作者信息

Qi Xiao, Niu Chong, Zhang Zi-Zheng, Chen Meng-Ru, Wang Feng-Ze, Fei Hong-Rong

机构信息

School of Pharmacy (Institute of Pharmaceutical Research), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.

School of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, PR China.

出版信息

Cell Biochem Biophys. 2025 Aug 29. doi: 10.1007/s12013-025-01850-y.

DOI:10.1007/s12013-025-01850-y

PMID:40879881

Abstract

摘要

相似文献

6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.

Cell Biochem Biophys. 2025 Aug 29. doi: 10.1007/s12013-025-01850-y.

Scutebarbatine B Exerts Anti-Breast Cancer Activity by Inducing Cell Cycle Arrest and Apoptosis Through Multiple Pathways.

Phytother Res. 2025 Jun 30. doi: 10.1002/ptr.70007.

6PPD and 6PPDQ exposure promote the proliferation and migration of non-small cell lung cancer cells through PTEN dysfunction and ARG2-mediated metabolic reprogramming.

J Hazard Mater. 2025 Sep 5;495:139088. doi: 10.1016/j.jhazmat.2025.139088. Epub 2025 Jun 27.

Nerolidol inhibits proliferation and triggers ROS-facilitated apoptosis in lung carcinoma cells via the suppression of MAPK/STAT3/NF-κB and P13K/AKT pathways.

Adv Clin Exp Med. 2024 Oct 21. doi: 10.17219/acem/190274.

Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.

Oncol Rep. 2016 Jul;36(1):90-8. doi: 10.3892/or.2016.4782. Epub 2016 Apr 28.

Benzyl isothiocyanate triggers apoptosis by initiating autophagy through the generation of ROS and modulating the MAPK and PI3K-AKT pathway in cervical cancer cells.

Int Immunopharmacol. 2025 Jul 21;163:115208. doi: 10.1016/j.intimp.2025.115208.

A Small Molecular Weight Saccharide Fraction From Panax quinquefolium L. Inhibited Non-Small Cell Lung Cancer via Endoplasmic Reticulum-Stress Mediated Apoptosis.

Phytother Res. 2025 Sep;39(9):3868-3885. doi: 10.1002/ptr.70036. Epub 2025 Jul 15.

SREBP-2 promotes cancer progression through the mevalonate-Akt pathway in non-small cell lung cancer.

Sci Rep. 2025 Jul 2;15(1):23103. doi: 10.1038/s41598-025-07437-0.

WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.

Cell Signal. 2024 Oct;122:111330. doi: 10.1016/j.cellsig.2024.111330. Epub 2024 Jul 31.

Melittin inactivates YAP/HIF-1α pathway via up-regulation of LATS2 to inhibit hypoxia-induced proliferation, glycolysis and angiogenesis in NSCLC.

Clinics (Sao Paulo). 2024 Jun 17;79:100407. doi: 10.1016/j.clinsp.2024.100407. eCollection 2024.

本文引用的文献

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3.

Nat Commun. 2025 Feb 6;16(1):1406. doi: 10.1038/s41467-025-56444-2.

Ethanolic extract of Akhuni induces ROS-mediated apoptosis through ERK and AKT signalling pathways: Insights from metabolic profiling and molecular docking studies.

Free Radic Biol Med. 2025 Feb 16;228:137-149. doi: 10.1016/j.freeradbiomed.2024.12.059. Epub 2024 Dec 31.

Global Disparities of Cancer and Its Projected Burden in 2050.

JAMA Netw Open. 2024 Nov 4;7(11):e2443198. doi: 10.1001/jamanetworkopen.2024.43198.

Scutellarein inhibits lung cancer growth by inducing cell apoptosis and inhibiting glutamine metabolic pathway.

J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118999. doi: 10.1016/j.jep.2024.118999. Epub 2024 Oct 28.

The oncogenic axis YAP/MYC/EZH2 impairs PTEN tumor suppression activity enhancing lung tumorigenicity.

Cell Death Discov. 2024 Oct 25;10(1):452. doi: 10.1038/s41420-024-02216-8.

Camptothecin and its derivatives: Advancements, mechanisms and clinical potential in cancer therapy.

Med Oncol. 2024 Oct 9;41(11):263. doi: 10.1007/s12032-024-02527-x.

Paclitaxel in colon cancer management: from conventional chemotherapy to advanced nanocarrier delivery systems.

Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9449-9474. doi: 10.1007/s00210-024-03256-8. Epub 2024 Jul 11.

Survivin (BIRC5): Implications in cancer therapy.

Life Sci. 2024 Aug 1;350:122788. doi: 10.1016/j.lfs.2024.122788. Epub 2024 Jun 5.

Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway.

Targeting PI3K/AKT/mTOR signaling to overcome drug resistance in cancer.

Chem Biol Interact. 2024 Jun 1;396:111055. doi: 10.1016/j.cbi.2024.111055. Epub 2024 May 17.

6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.

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6-Methoxydihydrosanguinarine Suppresses the Proliferation of Non-small Cell Lung Cancer Cells through Elevation of ROS and Activation of IRE1/JNK Signaling.

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