Wolitzky-Taylor Kate, Wen Alainna, Freimer Nelson, Craske Michelle G
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Neuropsychopharmacology. 2025 Aug 29. doi: 10.1038/s41386-025-02174-4.
Depressive and anxiety disorders are highly and increasingly prevalent among 18 to 25 years olds as individuals emerge into adulthood. If untreated, these conditions have potentially serious consequences for social, academic and occupational functioning and confer risk for various mental health and health conditions, rendering prevention and treatment of paramount importance. After reviewing the evidence for prevalence, chronicity and cost of anxiety and depression in this transitional developmental period, we present evidence for psychotherapeutic and pharmacological interventions that can effectively prevent and treat depression and anxiety. Next, we describe the major barriers to prevention and treatment in young adults that result in significant unmet need. To address this mental health gap, we describe a digitally-supported, stratified stepped care system designed to overcome barriers while also personalizing the prevention and treatment of anxiety and depression, called Screening and Treatment for Anxiety and Depression (STAND). We conclude with challenges in this field of research and future.
随着个体步入成年期,抑郁症和焦虑症在18至25岁人群中极为常见且愈发普遍。若不加以治疗,这些病症会对社交、学业和职业功能产生潜在的严重后果,并带来各种心理健康和健康问题的风险,因此预防和治疗至关重要。在审视了这一过渡发育阶段焦虑症和抑郁症的患病率、慢性病程及成本的相关证据后,我们展示了可有效预防和治疗抑郁症及焦虑症的心理治疗和药物干预的证据。接下来,我们描述了导致大量需求未得到满足的年轻人预防和治疗的主要障碍。为填补这一心理健康差距,我们描述了一种数字支持的分层阶梯式护理系统,旨在克服障碍,同时使焦虑症和抑郁症的预防和治疗个性化,即焦虑症和抑郁症筛查与治疗(STAND)。我们最后阐述了该研究领域的挑战及未来方向。