Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.
作者信息
Balta Denise, Varghese Anish, Prieto Huarcaya Susy, Di Spiezio Alessandro, Marques André R A, Akdaş Enes Yağız, Tabakacilar Doğa, Drobny Alice, Werner Christian, Xiang Wei, Mächtel Rebecca, Dobert Jan Philipp, Fejtova Anna, Richter Franziska, Küspert Melanie, Arnold Philipp, Saftig Paul, Zunke Friederike
机构信息
Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Neuroscience Institute, National Research Council (CNR), Padua, Italy.
出版信息
Mol Neurodegener. 2025 Aug 29;20(1):95. doi: 10.1186/s13024-025-00886-1.
PMID:40883786
Abstract
摘要
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