关节炎基金会互联网观察性研究：身体活动、疼痛与身体功能——研究方案
Observational Arthritis Foundation Internet Study: Physical Activity, Pain, and Physical Function- Study Protocol.
作者信息
Liles Sydney C, Copson Jennifer, Tore Nurten Gizem, White Daniel K
机构信息
Department of Physical Therapy, University of Delaware, Newark, DE, USA.
出版信息
medRxiv. 2025 Aug 21:2025.08.18.25333813. doi: 10.1101/2025.08.18.25333813.
BACKGROUND
Rheumatic diseases affect approximately 54 million adults in the United States and are a leading cause of pain and disability. Although physical activity is recommended to reduce pain and improve function, rheumatic diseases encompass over 100 conditions with different clinical presentations and medical management, possibly contributing to differences in exercise response. Few studies have included diverse samples across rheumatic diseases making direct comparisons in clinical presentation and activity level difficult.
OBJECTIVE
To evaluate the feasibility of internet recruitment, validate patient-reported diagnoses, and explore associations of physical activity with pain and function across rheumatic diseases in an online cohort of adults in the United States.
METHODS
The Observational Arthritis foundation Internet Study (OASIS): Physical Activity, Pain, and Physical Function study is an online cross-sectional observational study of adults with rheumatic diseases living in the US. Participants will be recruited using Meta ads, Arthritis Foundation mailing lists, and the ResearchMatch database. Participants will be considered eligible if they are ≥ 18 years old, live in the US, and have been diagnosed with a rheumatic disease by a physician. All participants will provide written informed consent and HIPAA release prior to participation. Participants will self-report all rheumatic diseases they have been diagnosed with, and diagnoses will be verified using provider confirmation or electronic medical records. Self-report questionnaires will be used to assess outcomes such as physical activity, pain, physical function, mental and physical health.
DISCUSSION
OASIS is the first study to comparison of physical activity, pain, and physical function across a range of rheumatic diseases in a single cohort. The results from this study could identify differences in presentation or inform tailored exercise recommendations for less common rheumatic diseases.
背景
在美国，风湿性疾病影响着约5400万成年人，是疼痛和残疾的主要原因。尽管建议进行体育活动以减轻疼痛并改善功能，但风湿性疾病涵盖100多种病症，具有不同的临床表现和医疗管理方式，这可能导致运动反应存在差异。很少有研究纳入各种风湿性疾病的样本，因此难以直接比较临床表现和活动水平。
目的
评估在美国成年人在线队列中通过互联网招募参与者的可行性，验证患者报告的诊断，并探讨体育活动与各种风湿性疾病的疼痛和功能之间的关联。
方法
观察性关节炎基金会互联网研究（OASIS）：体育活动、疼痛和身体功能研究是一项针对居住在美国的患有风湿性疾病的成年人的在线横断面观察性研究。将使用Meta广告、关节炎基金会邮件列表和ResearchMatch数据库招募参与者。如果参与者年龄≥18岁、居住在美国且已被医生诊断患有风湿性疾病，则将被视为符合条件。所有参与者在参与之前都将提供书面知情同意书和健康保险流通与责任法案（HIPAA）授权书。参与者将自行报告他们被诊断出的所有风湿性疾病，并将通过医疗服务提供者确认或电子病历对诊断进行核实。将使用自我报告问卷来评估体育活动、疼痛、身体功能、心理和身体健康等结果。
讨论
OASIS是第一项在单一队列中比较一系列风湿性疾病的体育活动、疼痛和身体功能的研究。这项研究的结果可以确定表现上的差异，或为不太常见的风湿性疾病提供量身定制的运动建议。
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