68Ga-FAPI-04与18F-FDG在原发性脾血管肉瘤中的比较

Comparison of 68Ga-FAPI-04 and 18F-FDG in Primary Splenic Angiosarcoma.

作者信息

Fang Tianxing, He Yong, Xiao Zhiwei, Lu Nan, Jiang Yaqun

机构信息

Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.

出版信息

Clin Nucl Med. 2025 Sep 1. doi: 10.1097/RLU.0000000000006100.

DOI:10.1097/RLU.0000000000006100

PMID:40902190

Abstract

Primary splenic angiosarcoma is a rare, aggressive tumor, characterized by rapid metastasis and poor prognosis. Herein, we report a case of 18F-FDG and 68Ga-FAPI-04 PET/CT imaging in a 57-year-old man with primary splenic angiosarcoma. 68Ga-FAPI-04 PET/CT presented much higher uptake in the lesions compared with 18F-FDG PET/CT, showing better diagnostic performance. Our case demonstrated the characteristics of 68Ga-FAPI-04 PET/CT in primary splenic angiosarcoma and suggested its potential as a more promising alternative to 18F-FDG PET/CT for diagnosis and a useful tool for clinical management.

摘要

原发性脾血管肉瘤是一种罕见的侵袭性肿瘤，其特点是转移迅速且预后不良。在此，我们报告一例57岁男性原发性脾血管肉瘤患者的18F-FDG和68Ga-FAPI-04 PET/CT成像情况。与18F-FDG PET/CT相比，68Ga-FAPI-04 PET/CT在病变部位的摄取明显更高，显示出更好的诊断性能。我们的病例展示了68Ga-FAPI-04 PET/CT在原发性脾血管肉瘤中的特点，并表明其作为18F-FDG PET/CT诊断的更有前景的替代方法以及临床管理的有用工具的潜力。