SND1, a novel m6A RNA regulator: Its high expression correlates with tumorigenesis and poor prognosis in head and neck squamous cell carcinoma.

BACKGROUND

The multifunctional protein SND1 (Staphylococcal Nuclease and Tudor Domain Containing 1) is involved in transcriptional control, RNA metabolism, and tumour development. While its role in several cancer types has been studied, little is known about its importance in head and neck squamous cell carcinoma (HNSCC). This study investigates the expression patterns, clinical relevance, and functional role of SND1 in HNSCC.

METHODS

SND1 expression in the TCGA-HNSCC dataset was examined using multiple databases, including TIMER, Protein Atlas, and UALCAN. Further SND1 expression was validated using real-time PCR. The prognostic impact of SND1 in HNSCC patients was analyzed using Kaplan-Meier survival analysis. Protein-protein interactions and pathway enrichment analyses were conducted to elucidate the SND1 functional role.

RESULTS

The expression of SND1 was significantly elevated in HNSCC tissues compared to normal tissues. Higher grade, metastasis, TP53 alterations, HPV status, and advanced tumour stage were all substantially associated with elevated SND1 expression. According to Kaplan-Meier analysis, a lower overall survival rate was linked to SND1 high expression. Analysis of protein interactions identified partners such as AGO2, FXR1, and STAT5, which connect SND1 to carcinogenic pathways including JAK-STAT signalling. Functional enrichment pathways indicated SND1 role in oncogene translation regulation and head and neck carcinoma.

CONCLUSION

SND1 overexpression in HNSCC indicates a poor prognosis and unfavorable clinicopathological features. Due to its role in key cancer pathways, SND1 could serve as a useful biomarker for prognosis and a potential target for treatment. Improving patient outcomes requires further research into its molecular mechanisms and the development of treatments.