肿瘤内外：胶质母细胞瘤诱导免疫抑制的机制
Within and beyond the tumor: Mechanisms of glioblastoma-induced immunosuppression.
作者信息
Puviindran Bhairavy J, Wallace Shannon, Ayasoufi Katayoun, Lerner Emily, Fecci Peter E
机构信息
Brain Tumor Immunotherapy Program, Duke University, Durham, North Carolina.
Department of Biomedical Engineering, Duke University, Durham, North Carolina.
出版信息
Neurooncol Adv. 2025 Sep 9;7(Suppl 4):iv4-iv18. doi: 10.1093/noajnl/vdaf006. eCollection 2025 Sep.
Immunotherapies have thus far proved of limited efficacy against glioblastoma. Failures can be attributed to a host of immunosuppressive mechanisms that are either directly employed by the tumor or are instead a convenient feature of the intracranial environment. This review aims to categorize glioblastoma immune-evasive tendencies, provide an update on our understanding of etiologies, and describe newer approaches to improving therapeutic responses.
迄今为止，免疫疗法对胶质母细胞瘤的疗效有限。治疗失败可归因于一系列免疫抑制机制，这些机制要么是肿瘤直接采用的，要么是颅内环境的一个便利特征。本综述旨在对胶质母细胞瘤的免疫逃逸倾向进行分类，更新我们对病因的理解，并描述改善治疗反应的新方法。
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