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感染与代谢功能障碍及相关脂肪性肝病发展之间的关系。

Relationship between infection and the development of metabolic dysfunction and associated steatotic liver disease.

作者信息

Raissa Noube Julie, Yao Shuo-Yi, Wang Fen

机构信息

Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China.

出版信息

World J Gastroenterol. 2025 Sep 7;31(33):110176. doi: 10.3748/wjg.v31.i33.110176.

Abstract

This research is to explore the relationship between () infection and the development of metabolic dysfunction and metabolic dysfunction-associated steatotic liver disease (MASLD), based on research by Ye . Their investigation analyzed the association of infection with obesity, glucose, lipids, blood pressure, and MASLD in Chinese adults, through a cross-sectional study of 28624 participants. Clinical data analysis demonstrated that -positive participants exhibited significantly higher ages, blood glucose, total cholesterol, low-density lipoprotein, body mass index, systolic and diastolic blood pressure levels, and greater MASLD detection rates compare to the -negative participants. These differences achieved statistical significance ( < 0.05). Multivariate analysis identified, elevated glucose, body mass index, and diastolic pressure as independent risk factors for infection, while high-density lipoprotein demonstrated protective effects. These findings suggest that infection may contribute to metabolic disturbances and MASLD.

摘要

本研究基于叶的研究,旨在探讨()感染与代谢功能障碍及代谢功能障碍相关脂肪性肝病(MASLD)发展之间的关系。他们的调查通过对28624名参与者的横断面研究,分析了中国成年人中感染与肥胖、血糖、血脂、血压及MASLD之间的关联。临床数据分析表明,与阴性参与者相比,阳性参与者的年龄、血糖、总胆固醇、低密度脂蛋白、体重指数、收缩压和舒张压水平显著更高,且MASLD检出率更高。这些差异具有统计学意义(<0.05)。多变量分析确定,血糖升高、体重指数和舒张压是感染的独立危险因素,而高密度脂蛋白具有保护作用。这些发现表明,感染可能导致代谢紊乱和MASLD。

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