阻力运动训练同样能提高健康绝经后女性和乳腺癌幸存者在6分钟步行测试中的工作效率，并测量次最大耗氧量。
Resistance exercise training similarly improves work efficiency and measured submaximal oxygen consumption during the 6-min walk test in healthy postmenopausal women and breast cancer survivors.
作者信息
Artigas-Arias Macarena, Muñoz-Cofre Rodrigo, Vidal-Seguel Nicolás, Alegría-Molina Andrea, Sapunar Jorge, Curi Rui, Marzuca-Nassr Gabriel Nasri
机构信息
Doctorado en Ciencias Mención Biología Celular y Molecular Aplicada, Facultad de Ciencias Agropecuarias, Universidad de La Frontera, Temuco, Chile.
Centro de Investigación E Innovación del Cáncer. Fundación Arturo López Pérez OECI Cancer Center, Santiago de Chile, Chile.
出版信息
Eur J Appl Physiol. 2025 Sep 16. doi: 10.1007/s00421-025-05966-0.
PURPOSE
This exploratory study aimed to examine the potential effects of a 12-week progressive whole-body resistance exercise training (RET) program on measured submaximal oxygen consumption (submaximal VO) and work efficiency during the 6-min walk test (6MWT) in healthy postmenopausal women and breast cancer survivors.
METHODS
Twenty-four postmenopausal women (Healthy, HEA; 54 ± 3 years; BMI 26.6 ± 2.7 kg·m; n = 13 and breast cancer survivors, BCS; 52 ± 5 years; BMI 26.8 ± 2.1 kg·m; n = 11) completed a 12-week RET program. Participants were assessed using the 6MWT with a PNOE® metabolic analyzer before and after the intervention. Metabolic and respiratory parameters, including submaximal VO and work efficiency were measured. Data were analyzed using repeated measures ANOVA.
RESULTS
Twelve-week RET improved the distance covered in the 6MWT by 10 ± 11% in the HEA group (from 586.6 ± 27.9 to 642.9 ± 35.9 m) and by 6 ± 16% in the BCS group (from 572.9 ± 62.6 to 604.7 ± 39.9 m) (P < 0.001; η = 0.54), with no significant differences between the groups (P = 0.175). There was an increase in RER (P < 0.001), ventilation (P = 0.043), and carbohydrate percentage (P < 0.001), along with a decrease in fat consumption percentage (P < 0.001), with no differences between groups (P > 0.05). After 12 weeks of RET, absolute submaximal VO decreased in both groups (P < 0.001), with no differences between them (P > 0.05). The maximum work rate increased (P < 0.001), with no differences between groups (P > 0.05). Work efficiency also improved over time (P < 0.05), with no differences between groups (P > 0.05).
CONCLUSION
As an exploratory analysis, these findings suggest that a 12-week RET program improved work efficiency and reduced measured submaximal VO during the 6MWT in both populations. The improvements were similar in healthy postmenopausal women and breast cancer survivors.
TRIAL REGISTRATION NUMBER
NCT05690295.
目的
本探索性研究旨在检验一项为期12周的渐进式全身抗阻运动训练（RET）计划对健康绝经后女性和乳腺癌幸存者在6分钟步行试验（6MWT）中的次最大摄氧量（次最大VO₂）和工作效率的潜在影响。
方法
24名绝经后女性（健康组，HEA；54±3岁；体重指数26.6±2.7kg·m²；n = 13）和乳腺癌幸存者（BCS组；52±5岁；体重指数26.8±2.1kg·m²；n = 11）完成了一项为期12周的RET计划。在干预前后，使用带有PNOE®代谢分析仪的6MWT对参与者进行评估。测量代谢和呼吸参数，包括次最大VO₂和工作效率。数据采用重复测量方差分析进行分析。
结果
为期12周的RET使HEA组在6MWT中行走的距离增加了10±11%（从586.6±27.9米增加到642.9±35.9米），BCS组增加了6±16%（从572.9±62.6米增加到604.7±39.9米）（P < 0.001；η = 0.54），两组之间无显著差异（P = 0.175）。呼吸交换率（RER）、通气量（P = 0.043）和碳水化合物百分比增加（P < 0.001），脂肪消耗百分比降低（P < 0.001），两组之间无差异（P > 0.05）。经过12周的RET后，两组的绝对次最大VO₂均下降（P < 0.001），两组之间无差异（P > 0.05）。最大工作率增加（P < 0.001），两组之间无差异（P > 0.05）。工作效率也随时间提高（P < 0.05），两组之间无差异（P > 0.05）。
结论
作为一项探索性分析，这些发现表明，为期12周的RET计划提高了两组人群在6MWT中的工作效率，并降低了测量的次最大VO₂。健康绝经后女性和乳腺癌幸存者的改善情况相似。
试验注册号
NCT05690295。
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