染色体外DNA在肿瘤发生和进展中的作用。
The role of extrachromosomal DNA in tumorigenesis and progression.
作者信息
Ma Xiaoyang, Yu Xiaolin, Wu Chuan, Song Lixing
机构信息
Department of Clinical Laboratory, Zigong Fourth People's Hospital, Zigong, China.
Sichuan Vocational College of Health and Rehabilitation, Zigong, China.
出版信息
Front Oncol. 2025 Sep 15;15:1665024. doi: 10.3389/fonc.2025.1665024. eCollection 2025.
In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells. Here, we provide a detailed review of the structure, genetics, occurrence, outcomes, and functions of ecDNA, offering further reference for research on ecDNA.
在肿瘤中，染色体外DNA（ecDNA）是癌基因表达、基因组不稳定、耐药性演变以及患者预后不良的重要驱动因素。ecDNA存在于多种肿瘤中，但在正常细胞中很少见。在此，我们对ecDNA的结构、遗传学、发生情况、结果及功能进行了详细综述，为ecDNA的研究提供进一步参考。
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