Ali Syed, Youn Alex, Black Benjamin, Black Dennis, Jensen Aaron, Swarup Ishaan
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA.
School of Medicine, University of California San Francisco, San Francisco, CA, USA.
J Pediatr Soc North Am. 2025 Sep 15;13:100269. doi: 10.1016/j.jposna.2025.100269. eCollection 2025 Nov.
There is currently no consensus regarding optimal treatment of femoral shaft fractures in the pediatric population, particularly regarding timing of surgical fixation. This large, retrospective database study seeks to identify predictors of delayed fixation of femoral shaft fractures in pediatric patients, and whether delayed fixation may be associated with certain complications.
Data were drawn from the American College of Surgeons Trauma Quality Improvement Program (TQIP) database. Pediatric patients with femoral shaft fractures were stratified based on the timing of surgical fixation: <24 h or ≥24 h from ED presentation. The association of surgical timing with demographics, injury characteristics, and complications was assessed by univariate analysis and a multivariate regression model.
Patients with ISS scores >15 ( < .01), worse GCS scores ( < .01), older age (10-16 years, = .02), and higher number of days on ventilator ( < .01) were more likely to have delayed fixation. The delayed fixation cohort showed significantly higher rates of complications, including DVT, PE, and pressure ulcer injury ( < .03). Patients who underwent delayed fixation were also more likely to have a complication ( < .01), and those with a more severe ISS (>15) and who spent longer days on a ventilator were more likely to have a complication ( < .01).
Our study demonstrates significant predictors of delayed fixation, in addition to showing a significant association with higher rates of complications. To our knowledge, this is the first study to use a large clinical database to assess predictors of femoral fracture timing and associated complications in the pediatric population.
(1)Optimal timing of surgical fixation of pediatric femoral shaft fractures has yet to be established.(2)This large, retrospective database study identifies significant predictors of delayed fixation: patients with ISS scores >15, worse GCS scores, older age, and higher number of days on a ventilator.(3)The median time to fixation was 33.85 h, and delayed fixation (≥24 h) was significantly associated with the development of various complications.
III.
目前对于小儿股骨干骨折的最佳治疗方法尚无共识,尤其是手术固定的时机。这项大型回顾性数据库研究旨在确定小儿股骨干骨折延迟固定的预测因素,以及延迟固定是否可能与某些并发症相关。
数据取自美国外科医师学会创伤质量改进计划(TQIP)数据库。小儿股骨干骨折患者根据手术固定时间分层:从急诊科就诊起<24小时或≥24小时。通过单因素分析和多因素回归模型评估手术时机与人口统计学、损伤特征及并发症之间的关联。
损伤严重度评分(ISS)>15分(P<.01)、格拉斯哥昏迷量表(GCS)评分较差(P<.01)、年龄较大(10 - 16岁,P =.02)以及机械通气天数较多(P<.01)的患者更有可能出现延迟固定。延迟固定组的并发症发生率显著更高,包括深静脉血栓形成(DVT)、肺栓塞(PE)和压疮损伤(P<.03)。接受延迟固定的患者也更有可能出现并发症(P<.01),而ISS评分更高(>15)且机械通气天数更长的患者更有可能出现并发症(P<.01)。
我们的研究证明了延迟固定的显著预测因素,此外还显示出与更高的并发症发生率存在显著关联。据我们所知,这是第一项使用大型临床数据库评估小儿股骨干骨折固定时间预测因素及相关并发症的研究。
(1)小儿股骨干骨折手术固定的最佳时机尚未确定。(2)这项大型回顾性数据库研究确定了延迟固定的显著预测因素:ISS评分>15分、GCS评分较差、年龄较大以及机械通气天数较多的患者。(3)固定的中位时间为33.85小时,延迟固定(≥24小时)与各种并发症的发生显著相关。
III级