伯基特氏瘤含有包裹着RNA指导的DNA聚合酶和高分子量病毒相关RNA的颗粒。
Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA.
作者信息
Kufe D, Magrath I T, Ziegler J L, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):737-41. doi: 10.1073/pnas.70.3.737.
Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that the viral-related RNA found in Burkitt's tumors is a 70S component encapsulated with RNA-instructed DNA polymerase in a particle possessing a density characteristic of RNA tumor viruses. Further, the DNA synthesized by the Burkitt particles hybridizes specifically to the RNA of Rauscher leukemia virus. Thus, four features characteristic of a known oncogenic RNA agent are also exhibited by particles found with a high (87%) frequency in Burkitt's tumors. The relation between the RNA particle and the Epstein-Barr virus and their etiological roles remains to be elucidated. However, relevant to these issues is the finding reported here that the presence of Epstein-Barr virus information in nonneoplastic cells does not lead to the production of the RNA particles that have been detected now in three different human neoplasias, including leukemias, breast cancer, and Burkitt's disease.
先前的研究表明，伯基特淋巴瘤与含DNA的爱泼斯坦-巴尔病毒有关，它含有一种在序列上与劳舍尔白血病病毒的RNA相关的RNA。本研究证实，在伯基特肿瘤中发现的病毒相关RNA是一种70S成分，它与RNA指导的DNA聚合酶一起包裹在一个具有RNA肿瘤病毒密度特征的颗粒中。此外，伯基特颗粒合成的DNA与劳舍尔白血病病毒的RNA特异性杂交。因此，在伯基特肿瘤中高频率（87%）发现的颗粒也表现出已知致癌RNA因子的四个特征。RNA颗粒与爱泼斯坦-巴尔病毒之间的关系及其病因学作用仍有待阐明。然而，与这些问题相关的是此处报道的一项发现，即在非肿瘤细胞中存在爱泼斯坦-巴尔病毒信息并不会导致现在在三种不同人类肿瘤（包括白血病、乳腺癌和伯基特病）中检测到的RNA颗粒的产生。
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