Golebiowska H, Rowe D S
Clin Exp Immunol. 1967 May;2(3):275-83.
Immunoelectrophoretic analysis of certain human sera revealed a deficiency of the fast migrating part of IgG. Sera studied were from individuals suspected of antibody deficiency. Deficiency of fast IgG was especially frequent in children in the second 6 months of life, but was not uncommon up to the age of 5 years. It was found in two adults. This deficiency was not related to serum IgG concentration. A second type of selective deficiency was noted in sera of IgG content of 200 mg/100 ml or less. Analysis of some of these sera, after concentration by ultrafiltration, showed an isolated deficiency of slow migrating IgG. The significance of these findings in relation to subclasses of IgG is discussed.
对某些人血清进行的免疫电泳分析显示，IgG快速迁移部分存在缺陷。所研究的血清来自疑似抗体缺乏的个体。快速IgG缺乏在出生后第二个6个月的儿童中尤为常见，但在5岁之前也并不罕见。在两名成年人中也发现了这种情况。这种缺乏与血清IgG浓度无关。在IgG含量为200mg/100ml或更低的血清中发现了第二种选择性缺乏类型。对其中一些经过超滤浓缩的血清进行分析后发现，存在孤立的慢速迁移IgG缺乏。讨论了这些发现与IgG亚类的关系。
