一种新型半合成抗生素：14-二乙氧基乙酰氧基柔红霉素（R.P. 33 921）的制备及其实验性抗肿瘤活性
[Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)].
作者信息
Maral R, Ducep J B, Farge D, Ponsinet G, Reisdorf D
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Feb 6;286(5):443-6.
PMID:418906
Abstract
14-diethoxyacetoxy daunorubicin (R.P. 33 921) was chosen among a series of new daunorubicin analogues. Its preparation from daunorubicin and its biological activities are described. It displays an antitumoral activity in mice with a better chemotherapeutic index than daunorubicin and doxorubicin.
摘要
在一系列新的柔红霉素类似物中选择了14 - 二乙氧基乙酰氧基柔红霉素（R.P. 33 921）。描述了其由柔红霉素制备的方法及其生物学活性。它在小鼠中显示出抗肿瘤活性，化疗指数优于柔红霉素和阿霉素。
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