肠道微生物群在胍基琥珀酸代谢中的作用。
Role of intestinal microflora in the metabolism of guanidinosuccinic acid.
作者信息
Milstien S, Goldman P
出版信息
J Bacteriol. 1973 May;114(2):641-4. doi: 10.1128/jb.114.2.641-644.1973.
Among a variety of bacteria isolated from the gastrointestinal tracts of rats and humans, only streptococci of group N are capable of degrading guanidinosuccinic acid added to their culture medium. The urinary excretion of guanidinosuccinic acid by germfree rats is greater than that of conventional rats. The excretion of this compound by gnotobiotic rats correlates with the capacity of their intestinal microflora to degrade guanidinosuccinic acid in culture. Thus, guanidinosuccinic acid excretion is low in rats infected exclusively with Streptococcus faecalis, and the excretion is not altered when germfree rats are infected with an organism unable to degrade guanidinosuccinic acid (Lactobacillus). These findings suggest that the intestinal microflora, particularly Streptococcus, play a role in the metabolism of guanidinosuccinic acid by the host.
在从大鼠和人类胃肠道分离出的多种细菌中，只有N群链球菌能够降解添加到其培养基中的胍基琥珀酸。无菌大鼠尿中胍基琥珀酸的排泄量大于普通大鼠。悉生大鼠对该化合物的排泄与它们肠道微生物群在培养物中降解胍基琥珀酸的能力相关。因此，仅感染粪链球菌的大鼠胍基琥珀酸排泄量低，而无菌大鼠感染不能降解胍基琥珀酸的微生物（乳酸杆菌）时，排泄量没有改变。这些发现表明，肠道微生物群，尤其是链球菌，在宿主对胍基琥珀酸的代谢中起作用。
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