Hoq M S, Anderton J L, Cunningham M, Cash J D
Br Med J. 1974 Jun 8;2(5918):535-8. doi: 10.1136/bmj.2.5918.535.
Using a radial immunodiffusion technique we measured the urinary concentration of material related to complement (C3), IgM, and IgG along with fibrin-fibrinogen degradation products and heterophile (sheep) haemagglutinins in 15 patients with proliferative glomerulonephritis and in 10 patients after renal transplantation. There was a significant correlation between all variables measured, and serial studies showed that with the exception of IgG-related materials potentially useful information could be obtained on the detection of rejection and the response to treatment in both conditions. The significance of these observations is discussed.
我们采用放射免疫扩散技术,测定了15例增殖性肾小球肾炎患者和10例肾移植患者尿液中与补体(C3)、IgM、IgG相关物质的浓度,以及纤维蛋白 - 纤维蛋白原降解产物和嗜异性(绵羊)血凝素的浓度。所测的所有变量之间存在显著相关性,系列研究表明,除了与IgG相关的物质外,在这两种情况下,均可通过检测获得有关排斥反应及治疗反应的潜在有用信息。本文讨论了这些观察结果的意义。