缬氨霉素对高钾和低钾绵羊红细胞钾和钠通透性的影响。
The effect of valinomycin on potassium and sodium permeability of HK and LK sheep red cells.
作者信息
Tosteson D C, Cook P, Andreoli T, Tieffenberg M
出版信息
J Gen Physiol. 1967 Dec;50(11):2513-25. doi: 10.1085/jgp.50.11.2513.
Abstract
A cyclic depsipeptide antibiotic, valinomycin, was found to produce increased selective permeability of the plasma membranes of HK and LK sheep red blood cells to potassium but not to sodium ions. The compound had relatively little effect on the active extrusion of sodium from HK sheep red blood cells or on the Na + K-stimulated ATPase activity of membranes derived from these cells. It is proposed that the selective cation permeability produced by this compound depends primarily on steric factors, particularly the relationship between the diameter of the ring and the effective diameter of the ion. The significance of these results for the problem of the mechanism of ionic selectivity in natural membranes is discussed.
摘要
一种环状缩酚酸肽抗生素，缬氨霉素，被发现可使HK和LK绵羊红细胞的质膜对钾离子而非钠离子的选择性通透性增加。该化合物对HK绵羊红细胞中钠离子的主动排出或对源自这些细胞的膜的Na + K刺激的ATP酶活性影响相对较小。有人提出，该化合物产生的选择性阳离子通透性主要取决于空间因素，特别是环的直径与离子有效直径之间的关系。讨论了这些结果对于天然膜中离子选择性机制问题的意义。
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