5-羟色胺在化合物48/80对大鼠股血管的血管收缩作用中的作用。
Role of 5-hydroxytryptamine in the vasoconstrictor action of compound 48/80 in the rat femoral vasculature.
作者信息
Sakai K
出版信息
Br J Pharmacol. 1979 Mar;65(3):363-6. doi: 10.1111/j.1476-5381.1979.tb07839.x.
Abstract
- The effect of compound 48/80 on the rat femoral vasculature was examined by means of a cross-circulation technique. 2. Intra-arterial injection of increasing doses (1.5 to 15 microgram) of compound 48/80 caused dose-dependent vasoconstriction preceded by transient vasodilatation. The vasoconstriction was significantly reduced in reserpine-treated preparations and converted to vasodilatation by methysergide. 3. When the vasoconstrictor response to a large dose (300 microgram) of adenosine was abolished by repeated administration, the response to compound 48/80 remained unaltered. 4. The present results indicate that the femoral arterial vasoconstriction by compound 48/80 in the rat is mediated by the release of 5-hydroxytryptamine (5-HT); this 5-HT may be liberated from a different storage site from that released by adenosine.
摘要
- 采用交叉循环技术研究了化合物48/80对大鼠股血管的作用。2. 动脉内注射递增剂量（1.5至15微克）的化合物48/80会引起剂量依赖性血管收缩，之前有短暂的血管舒张。在利血平处理的制剂中，血管收缩明显减弱，而麦角新碱可将其转变为血管舒张。3. 当通过反复给药消除对大剂量（300微克）腺苷的血管收缩反应时，对化合物48/80的反应保持不变。4. 目前的结果表明，大鼠中化合物48/80引起的股动脉血管收缩是由5-羟色胺（5-HT）的释放介导的；这种5-HT可能从与腺苷释放不同的储存部位释放出来。
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本文引用的文献
1
Compound 48/80: a potent histamine liberator.化合物48/80：一种强效组胺释放剂。
Br J Pharmacol Chemother. 1951 Sep;6(3):499-508. doi: 10.1111/j.1476-5381.1951.tb00661.x.
2
Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators.鸦片生物碱及其他组胺释放剂对猫皮肤和肌肉中组胺的释放作用。
J Physiol. 1951 Aug;114(4):490-509. doi: 10.1113/jphysiol.1951.sp004639.
3
STUDIES ON THE MECHANISM OF ANAPHYLAXIS: A POSSIBLE BASIS FOR A PHARMACOLOGIC APPROACH TO ALLERGY.过敏反应机制研究：一种药理学治疗过敏方法的可能基础。
Clin Pharmacol Ther. 1963 Nov-Dec;4:749-83. doi: 10.1002/cpt196346749.
4
Release of serotonin and catecholamines by drugs.药物引起的血清素和儿茶酚胺释放。
Pharmacol Rev. 1962 Dec;14:531-50.
5
The effects of reserpine and compound 48/80 on the release of amines from the mast cells of rats.利血平和48/80对大鼠肥大细胞胺释放的影响。
Br J Pharmacol Chemother. 1956 Dec;11(4):411-6. doi: 10.1111/j.1476-5381.1956.tb00008.x.
6
Disposition of histamine in mammalian blood vessels.组胺在哺乳动物血管中的分布。
J Pharmacol Exp Ther. 1972 Aug;182(2):239-45.
7
Mechanisms of histamine release by compound 48-80.化合物48-80释放组胺的机制。
Br J Pharmacol. 1970 Jan;38(1):253-62. doi: 10.1111/j.1476-5381.1970.tb10354.x.
8
Selective release of histamine from rat mast cells by compound 48-80 and anitgen.化合物48-80和抗原诱导大鼠肥大细胞组胺的选择性释放
Am J Physiol. 1969 Mar;216(3):453-9. doi: 10.1152/ajplegacy.1969.216.3.453.
9
Tryptaminergic mechanism participating in induction of vasoconstriction by adenine nucleotides, adenosine, IMP and inosine in the isolated and blood-perfused hindlimb preparation of the rat.参与腺嘌呤核苷酸、腺苷、肌苷酸和肌苷在大鼠离体和血液灌注后肢制备中诱导血管收缩的色胺能机制。
Jpn J Pharmacol. 1978 Aug;28(4):579-87. doi: 10.1254/jjp.28.579.
10
Vasoconstriction after adenosine and inosine in the rat isolated hindlimb abolished by blockade of tryptaminergic mechanisms.在大鼠离体后肢中，腺苷和肌苷引起的血管收缩被色胺能机制的阻断所消除。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):55-9. doi: 10.1007/BF00586597.
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