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一些用于研究麻醉剂对动物作用的电生理方法,特别提及工业溶剂:综述。

Some electrophysiological methods for studying the action of narcotic agents in animals, with special reference to industrial solvents: a review.

作者信息

Mikisková H, Mikiska A

出版信息

Br J Ind Med. 1968 Apr;25(2):81-105. doi: 10.1136/oem.25.2.81.

Abstract

Four electrophysiological methods, two based on stimulation (measurement of spinal reflex excitability and of direct excitability of the cerebral motor cortex) and two based on bioelectric recording (electro-encephalography and electrocardiography), were used in intact guinea-pigs and rabbits for studying the action of narcotic and anaesthetic agents, especially of industrial solvents. The authors' results have been reviewed and compared with those of other investigators in an attempt to work out experimental procedures for routine toxicity testing.

摘要

在完整的豚鼠和兔子身上,使用了四种电生理方法,其中两种基于刺激(测量脊髓反射兴奋性和大脑运动皮层的直接兴奋性),另外两种基于生物电记录(脑电图和心电图),以研究麻醉剂和麻醉药物,尤其是工业溶剂的作用。作者的研究结果已被回顾,并与其他研究者的结果进行了比较,试图制定出常规毒性测试的实验程序。

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本文引用的文献

1
The electrocardiogram of the guinea-pig.豚鼠的心电图。
J Physiol. 1938 Apr 14;92(3):268-72. doi: 10.1113/jphysiol.1938.sp003601.
2
Nerve endings in mammalian muscle.哺乳动物肌肉中的神经末梢。
J Physiol. 1933 Apr 13;78(1):1-53. doi: 10.1113/jphysiol.1933.sp002984.
7
Trichlorethylene anaesthesia.三氯乙烯麻醉
Anesthesiology. 1960 Jan-Feb;21:67-77. doi: 10.1097/00000542-196001000-00013.
9
Biochemical mechanisms in chronic carbon disulfide poisoning.慢性二硫化碳中毒的生化机制
Am Ind Hyg Assoc J. 1959 Aug;20(4):303-23. doi: 10.1080/00028895909343722.
10
Theories of narcosis.麻醉理论。
Anesthesiology. 1959 Mar-Apr;20(2):204-13. doi: 10.1097/00000542-195903000-00011.

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