传染性单核细胞增多症患儿及其接触者中EBV抗体的血清学反应。
Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts.
作者信息
Joncas J, Mitnyan C
出版信息
Can Med Assoc J. 1970 Jun 6;102(12):1260-3.
The EBV antibodies were measured in 378 sera from a group of 129 pediatric and older cases of infectious mononucleosis and from 117 family and social contacts. Cases of infectious mononucleosis with only one exception were EBV seropositive in acute and/or convalescent sera. Fourteen cases, however, from whom no convalescent serum was available were EBV seronegative. A rise in EBV antibodies of two dilutions or more was demonstrated in 15 of the 129 cases. The prevalence of these antibodies in contacts reached 50 to 70% in each of four age groups. A significant antibody rise was encountered in only four cases, one of whom was found to have infectious mononucleosis simultaneously with the index case and one after an interdisease period of 10 months. The infectivity of the EB virus (and of infectious mononucleosis if causally related) and its horizontal transmission seem to be as low in nature as they appear to be experimentally in the laboratory.
对一组129例儿童及年长的传染性单核细胞增多症病例以及117名家属和社会接触者的378份血清进行了EB病毒抗体检测。传染性单核细胞增多症病例中，除1例例外，急性和/或恢复期血清的EB病毒血清学检测均为阳性。然而，有14例无法获得恢复期血清的病例，其EB病毒血清学检测为阴性。129例病例中有15例的EB病毒抗体升高了两个或更多稀释度。在四个年龄组中，这些抗体在接触者中的流行率均达到50%至70%。仅在4例中出现了显著的抗体升高，其中1例与索引病例同时患有传染性单核细胞增多症，另1例在发病间隔10个月后患病。EB病毒的传染性（以及如果存在因果关系的传染性单核细胞增多症的传染性）及其水平传播在自然环境中的程度似乎与在实验室中的实验结果一样低。
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